Roberts E - Search Results

1

Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza.

Marsolais D, Hahm B, Edelmann KH, Walsh KB, Guerrero M, Hatta Y, Kawaoka Y, Roberts E, Oldstone MB, Rosen H. Marsolais D, et al. Among authors: roberts e. Mol Pharmacol. 2008 Sep;74(3):896-903. doi: 10.1124/mol.108.048769. Epub 2008 Jun 24. Mol Pharmacol. 2008. PMID: 18577684 Free PMC article.

2

Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues.

Don AS, Martinez-Lamenca C, Webb WR, Proia RL, Roberts E, Rosen H. Don AS, et al. Among authors: roberts e. J Biol Chem. 2007 May 25;282(21):15833-42. doi: 10.1074/jbc.M609124200. Epub 2007 Mar 30. J Biol Chem. 2007. PMID: 17400555 Free article.

3

Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions.

Gonzalez-Cabrera PJ, Jo E, Sanna MG, Brown S, Leaf N, Marsolais D, Schaeffer MT, Chapman J, Cameron M, Guerrero M, Roberts E, Rosen H. Gonzalez-Cabrera PJ, et al. Among authors: roberts e. Mol Pharmacol. 2008 Nov;74(5):1308-18. doi: 10.1124/mol.108.049783. Epub 2008 Aug 15. Mol Pharmacol. 2008. PMID: 18708635 Free PMC article.

4

Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats.

Edwards S, Guerrero M, Ghoneim OM, Roberts E, Koob GF. Edwards S, et al. Among authors: roberts e. Addict Biol. 2012 Jan;17(1):76-85. doi: 10.1111/j.1369-1600.2010.00291.x. Epub 2011 Feb 11. Addict Biol. 2012. PMID: 21309953 Free PMC article.

5

Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists.

Guerrero M, Urbano M, Velaparthi S, Zhao J, Schaeffer MT, Brown S, Rosen H, Roberts E. Guerrero M, et al. Among authors: roberts e. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3632-6. doi: 10.1016/j.bmcl.2011.04.097. Epub 2011 Apr 28. Bioorg Med Chem Lett. 2011. PMID: 21570287 Free PMC article.

6

SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P₄) receptor.

Urbano M, Guerrero M, Zhao J, Velaparthi S, Schaeffer MT, Brown S, Rosen H, Roberts E. Urbano M, et al. Among authors: roberts e. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5470-4. doi: 10.1016/j.bmcl.2011.06.132. Epub 2011 Jul 13. Bioorg Med Chem Lett. 2011. PMID: 21783362 Free PMC article.

7

Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection.

Teijaro JR, Walsh KB, Cahalan S, Fremgen DM, Roberts E, Scott F, Martinborough E, Peach R, Oldstone MB, Rosen H. Teijaro JR, et al. Among authors: roberts e. Cell. 2011 Sep 16;146(6):980-91. doi: 10.1016/j.cell.2011.08.015. Cell. 2011. PMID: 21925319 Free PMC article.

8

Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype.

Urbano M, Guerrero M, Velaparthi S, Crisp M, Chase P, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E. Urbano M, et al. Among authors: roberts e. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6739-45. doi: 10.1016/j.bmcl.2011.09.049. Epub 2011 Sep 20. Bioorg Med Chem Lett. 2011. PMID: 21982495 Free PMC article.

9

Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonists.

Guerrero M, Urbano M, Zhao J, Crisp M, Chase P, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E. Guerrero M, et al. Among authors: roberts e. Bioorg Med Chem Lett. 2012 Jan 1;22(1):537-42. doi: 10.1016/j.bmcl.2011.10.096. Epub 2011 Nov 4. Bioorg Med Chem Lett. 2012. PMID: 22119461 Free PMC article.

10

Novel selective allosteric and bitopic ligands for the S1P(3) receptor.

Jo E, Bhhatarai B, Repetto E, Guerrero M, Riley S, Brown SJ, Kohno Y, Roberts E, Schürer SC, Rosen H. Jo E, et al. Among authors: roberts e. ACS Chem Biol. 2012 Dec 21;7(12):1975-83. doi: 10.1021/cb300392z. Epub 2012 Sep 14. ACS Chem Biol. 2012. PMID: 22971058 Free PMC article.

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