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A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity.
Ziegelbauer K, Gantner F, Lukacs NW, Berlin A, Fuchikami K, Niki T, Sakai K, Inbe H, Takeshita K, Ishimori M, Komura H, Murata T, Lowinger T, Bacon KB. Ziegelbauer K, et al. Among authors: niki t. Br J Pharmacol. 2005 May;145(2):178-92. doi: 10.1038/sj.bjp.0706176. Br J Pharmacol. 2005. PMID: 15753951 Free PMC article.
Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis.
Seki M, Oomizu S, Sakata KM, Sakata A, Arikawa T, Watanabe K, Ito K, Takeshita K, Niki T, Saita N, Nishi N, Yamauchi A, Katoh S, Matsukawa A, Kuchroo V, Hirashima M. Seki M, et al. Among authors: niki t. Clin Immunol. 2008 Apr;127(1):78-88. doi: 10.1016/j.clim.2008.01.006. Epub 2008 Feb 20. Clin Immunol. 2008. PMID: 18282810
Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions.
Nagahara K, Arikawa T, Oomizu S, Kontani K, Nobumoto A, Tateno H, Watanabe K, Niki T, Katoh S, Miyake M, Nagahata S, Hirabayashi J, Kuchroo VK, Yamauchi A, Hirashima M. Nagahara K, et al. Among authors: niki t. J Immunol. 2008 Dec 1;181(11):7660-9. doi: 10.4049/jimmunol.181.11.7660. J Immunol. 2008. PMID: 19017954 Free PMC article.
501 results