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Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice.
Burgess B, Naus K, Chan J, Hirsch-Reinshagen V, Tansley G, Matzke L, Chan B, Wilkinson A, Fan J, Donkin J, Balik D, Tanaka T, Ou G, Dyer R, Innis S, McManus B, Lütjohann D, Wellington C. Burgess B, et al. Among authors: chan b, chan j. Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1731-7. doi: 10.1161/ATVBAHA.108.168542. Epub 2008 Jul 3. Arterioscler Thromb Vasc Biol. 2008. PMID: 18599800
Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain.
Hirsch-Reinshagen V, Zhou S, Burgess BL, Bernier L, McIsaac SA, Chan JY, Tansley GH, Cohn JS, Hayden MR, Wellington CL. Hirsch-Reinshagen V, et al. J Biol Chem. 2004 Sep 24;279(39):41197-207. doi: 10.1074/jbc.M407962200. Epub 2004 Jul 21. J Biol Chem. 2004. PMID: 15269218 Free article.
The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein.
Tansley GH, Burgess BL, Bryan MT, Su Y, Hirsch-Reinshagen V, Pearce J, Chan JY, Wilkinson A, Evans J, Naus KE, McIsaac S, Bromley K, Song W, Yang HC, Wang N, DeMattos RB, Wellington CL. Tansley GH, et al. Among authors: chan jy. J Lipid Res. 2007 May;48(5):1022-34. doi: 10.1194/jlr.M600542-JLR200. Epub 2007 Feb 10. J Lipid Res. 2007. PMID: 17293612 Free article.
ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo.
Burgess BL, Parkinson PF, Racke MM, Hirsch-Reinshagen V, Fan J, Wong C, Stukas S, Theroux L, Chan JY, Donkin J, Wilkinson A, Balik D, Christie B, Poirier J, Lütjohann D, Demattos RB, Wellington CL. Burgess BL, et al. Among authors: chan jy. J Lipid Res. 2008 Jun;49(6):1254-67. doi: 10.1194/jlr.M700481-JLR200. Epub 2008 Feb 26. J Lipid Res. 2008. PMID: 18314463 Free article.
ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice.
Donkin JJ, Stukas S, Hirsch-Reinshagen V, Namjoshi D, Wilkinson A, May S, Chan J, Fan J, Collins J, Wellington CL. Donkin JJ, et al. Among authors: chan j. J Biol Chem. 2010 Oct 29;285(44):34144-54. doi: 10.1074/jbc.M110.108100. Epub 2010 Aug 25. J Biol Chem. 2010. PMID: 20739291 Free PMC article.
Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma.
Burgess BL, McIsaac SA, Naus KE, Chan JY, Tansley GH, Yang J, Miao F, Ross CJ, van Eck M, Hayden MR, van Nostrand W, St George-Hyslop P, Westaway D, Wellington CL. Burgess BL, et al. Among authors: chan jy. Neurobiol Dis. 2006 Oct;24(1):114-27. doi: 10.1016/j.nbd.2006.06.007. Epub 2006 Aug 8. Neurobiol Dis. 2006. PMID: 16899370
Hormonal modulators of glial ABCA1 and apoE levels.
Fan J, Shimizu Y, Chan J, Wilkinson A, Ito A, Tontonoz P, Dullaghan E, Galea LA, Pfeifer T, Wellington CL. Fan J, et al. Among authors: chan j. J Lipid Res. 2013 Nov;54(11):3139-50. doi: 10.1194/jlr.M042473. Epub 2013 Sep 2. J Lipid Res. 2013. PMID: 23999864 Free PMC article.
LCAT deficiency does not impair amyloid metabolism in APP/PS1 mice.
Stukas S, Freeman L, Lee M, Wilkinson A, Ossoli A, Vaisman B, Demosky S, Chan J, Hirsch-Reinshagen V, Remaley AT, Wellington CL. Stukas S, et al. Among authors: chan j. J Lipid Res. 2014 Aug;55(8):1721-9. doi: 10.1194/jlr.M049940. Epub 2014 Jun 20. J Lipid Res. 2014. PMID: 24950691 Free PMC article.
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