Leissring MA - Search Results

1

Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin.

Betts V, Leissring MA, Dolios G, Wang R, Selkoe DJ, Walsh DM. Betts V, et al. Among authors: leissring ma. Neurobiol Dis. 2008 Sep;31(3):442-50. doi: 10.1016/j.nbd.2008.06.001. Epub 2008 Jun 17. Neurobiol Dis. 2008. PMID: 18602473 Free PMC article.

2

Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life.

Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, Walsh DM. Shankar GM, et al. Among authors: leissring ma. Neurobiol Dis. 2009 Nov;36(2):293-302. doi: 10.1016/j.nbd.2009.07.021. Epub 2009 Aug 4. Neurobiol Dis. 2009. PMID: 19660551 Free PMC article.

3

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, Frosch MP, Selkoe DJ. Leissring MA, et al. Neuron. 2003 Dec 18;40(6):1087-93. doi: 10.1016/s0896-6273(03)00787-6. Neuron. 2003. PMID: 14687544 Free article.

4

Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy.

Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ. Farris W, et al. Among authors: leissring ma. Am J Pathol. 2007 Jul;171(1):241-51. doi: 10.2353/ajpath.2007.070105. Am J Pathol. 2007. PMID: 17591969 Free PMC article.

5

Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays.

Leissring MA, Lu A, Condron MM, Teplow DB, Stein RL, Farris W, Selkoe DJ. Leissring MA, et al. J Biol Chem. 2003 Sep 26;278(39):37314-20. doi: 10.1074/jbc.M305627200. Epub 2003 Jul 16. J Biol Chem. 2003. PMID: 12867419 Free article.

6

Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families.

Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE. Kim M, et al. Among authors: leissring ma. J Biol Chem. 2007 Mar 16;282(11):7825-32. doi: 10.1074/jbc.M609168200. Epub 2007 Jan 22. J Biol Chem. 2007. PMID: 17244626 Free article.

7

Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.

Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi RE, Selkoe DJ. Farris W, et al. Among authors: leissring ma. Am J Pathol. 2004 Apr;164(4):1425-34. doi: 10.1016/s0002-9440(10)63229-4. Am J Pathol. 2004. PMID: 15039230 Free PMC article.

8

Structural biology: enzyme target to latch on to.

Leissring MA, Selkoe DJ. Leissring MA, et al. Nature. 2006 Oct 19;443(7113):761-2. doi: 10.1038/nature05210. Nature. 2006. PMID: 17051198 No abstract available.

9

Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein.

Farris W, Leissring MA, Hemming ML, Chang AY, Selkoe DJ. Farris W, et al. Among authors: leissring ma. Biochemistry. 2005 May 3;44(17):6513-25. doi: 10.1021/bi0476578. Biochemistry. 2005. PMID: 15850385

10

Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening.

Cabrol C, Huzarska MA, Dinolfo C, Rodriguez MC, Reinstatler L, Ni J, Yeh LA, Cuny GD, Stein RL, Selkoe DJ, Leissring MA. Cabrol C, et al. Among authors: leissring ma. PLoS One. 2009;4(4):e5274. doi: 10.1371/journal.pone.0005274. Epub 2009 Apr 22. PLoS One. 2009. PMID: 19384407 Free PMC article.

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