Prakesch M - Search Results

1

The discovery of small molecule chemical probes of Bcl-X(L) and Mcl-1.

Prakesch M, Denisov AY, Naim M, Gehring K, Arya P. Prakesch M, et al. Bioorg Med Chem. 2008 Aug 1;16(15):7443-9. doi: 10.1016/j.bmc.2008.06.023. Epub 2008 Jun 18. Bioorg Med Chem. 2008. PMID: 18603434

2

Part 1. modular approach to obtaining diverse tetrahydroquinoline-derived polycyclic skeletons for use in high-throughput generation of natural-product-like chemical probes.

Prakesch M, Sharma U, Sharma M, Khadem S, Leek DM, Arya P. Prakesch M, et al. J Comb Chem. 2006 Sep-Oct;8(5):715-34. doi: 10.1021/cc060055i. J Comb Chem. 2006. PMID: 16961410 Free article.

3

Part 2: building diverse natural-product-like architectures from a tetrahydroaminoquinoline scaffold. Modular solution- and solid-phase approaches for use in high-throughput generation of chemical probes.

Sharma U, Srivastava S, Prakesch M, Sharma M, Leek DM, Arya P. Sharma U, et al. Among authors: prakesch m. J Comb Chem. 2006 Sep-Oct;8(5):735-61. doi: 10.1021/cc060056a. J Comb Chem. 2006. PMID: 16961411

4

Part 3. a novel stereocontrolled, in situ, solution- and solid-phase, Aza Michael approach for high-throughput generation of tetrahydroaminoquinoline-derived natural-product-like architectures.

Prakesch M, Srivastava S, Leek DM, Arya P. Prakesch M, et al. J Comb Chem. 2006 Sep-Oct;8(5):762-73. doi: 10.1021/cc060059n. J Comb Chem. 2006. PMID: 16961412 Free article.

5

Reagent-based, modular, tandem Michael approach for obtaining different indoline alkaloid-inspired polycyclic architectures.

Brochu JL, Prakesch M, Enright GD, Leek DM, Arya P. Brochu JL, et al. Among authors: prakesch m. J Comb Chem. 2008 May-Jun;10(3):405-20. doi: 10.1021/cc800036w. Epub 2008 Apr 18. J Comb Chem. 2008. PMID: 18419163

6

Building skeletally diverse architectures on the Indoline Scaffold: the discovery of a chemical probe of focal adhesion kinase signaling networks.

Prakesch M, Bijian K, Campagna-Slater V, Quevillon S, Joseph R, Wei CQ, Sesmilo E, Reayi A, Poondra RR, Barnes ML, Leek DM, Xu B, Lougheed C, Schapira M, Alaoui-Jamali M, Arya P. Prakesch M, et al. Bioorg Med Chem. 2008 Nov 1;16(21):9596-602. doi: 10.1016/j.bmc.2008.09.025. Epub 2008 Sep 12. Bioorg Med Chem. 2008. PMID: 18835181

7

Discovery of indoline-based, natural-product-like compounds as probes of focal adhesion kinase signaling pathways.

Poondra RR, Kumar NN, Bijian K, Prakesch M, Campagna-Slater V, Reayi A, Reddy PT, Choudhry A, Barnes ML, Leek DM, Daroszewska M, Lougheed C, Xu B, Schapira M, Alaoui-Jamali MA, Arya P. Poondra RR, et al. Among authors: prakesch m. J Comb Chem. 2009 Mar 9;11(2):303-9. doi: 10.1021/cc8001525. J Comb Chem. 2009. PMID: 19146410

8

Advances in solution- and solid-phase synthesis toward the generation of natural product-like libraries.

Nandy JP, Prakesch M, Khadem S, Reddy PT, Sharma U, Arya P. Nandy JP, et al. Among authors: prakesch m. Chem Rev. 2009 May;109(5):1999-2060. doi: 10.1021/cr800188v. Chem Rev. 2009. PMID: 19249849 Review. No abstract available.

9

Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma.

Uehling DE, Joseph B, Chung KC, Zhang AX, Ler S, Prakesch MA, Poda G, Grouleff J, Aman A, Kiyota T, Leung-Hagesteijn C, Konda JD, Marcellus R, Griffin C, Subramaniam R, Abibi A, Strathdee CA, Isaac MB, Al-Awar R, Tiedemann RE. Uehling DE, et al. Among authors: prakesch ma. J Med Chem. 2021 Aug 12;64(15):11129-11147. doi: 10.1021/acs.jmedchem.1c00506. Epub 2021 Jul 22. J Med Chem. 2021. PMID: 34291633

10

Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor.

Mamai A, Chau AM, Wilson BJ, Watson ID, Joseph BB, Subramanian PR, Morshed MM, Morin JA, Prakesch MA, Lu T, Connolly P, Kuntz DA, Pomroy NC, Poda G, Nguyen K, Marcellus R, Strathdee G, Theriault B, Subramaniam R, Mohammed M, Abibi A, Chan M, Winston J, Kiyota T, Undzys E, Aman A, Austin N, Du Jardin M, Packman K, Phillippar U, Attar R, Edwards J, O'Meara J, Uehling DE, Al-Awar R, Privé GG, Isaac MB. Mamai A, et al. Among authors: prakesch ma. ACS Med Chem Lett. 2023 Jan 12;14(2):199-210. doi: 10.1021/acsmedchemlett.2c00502. eCollection 2023 Feb 9. ACS Med Chem Lett. 2023. PMID: 36793435 Free PMC article.

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