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Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.
Di Fiore A, Pedone C, D'Ambrosio K, Scozzafava A, De Simone G, Supuran CT. Di Fiore A, et al. Among authors: pedone c. Bioorg Med Chem Lett. 2006 Jan 15;16(2):437-42. doi: 10.1016/j.bmcl.2005.09.040. Epub 2005 Nov 14. Bioorg Med Chem Lett. 2006. PMID: 16290146
Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties.
Di Fiore A, Scozzafava A, Winum JY, Montero JL, Pedone C, Supuran CT, De Simone G. Di Fiore A, et al. Among authors: pedone c. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1726-31. doi: 10.1016/j.bmcl.2006.12.099. Epub 2007 Jan 8. Bioorg Med Chem Lett. 2007. PMID: 17251017
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.
Di Fiore A, Pedone C, Antel J, Waldeck H, Witte A, Wurl M, Scozzafava A, Supuran CT, De Simone G. Di Fiore A, et al. Among authors: pedone c. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2669-74. doi: 10.1016/j.bmcl.2008.03.023. Epub 2008 Mar 18. Bioorg Med Chem Lett. 2008. PMID: 18359629
621 results