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An integrated platform of genomic assays reveals small-molecule bioactivities.
Hoon S, Smith AM, Wallace IM, Suresh S, Miranda M, Fung E, Proctor M, Shokat KM, Zhang C, Davis RW, Giaever G, St Onge RP, Nislow C. Hoon S, et al. Among authors: smith am. Nat Chem Biol. 2008 Aug;4(8):498-506. doi: 10.1038/nchembio.100. Epub 2008 Jul 11. Nat Chem Biol. 2008. PMID: 18622389
Quantitative phenotyping via deep barcode sequencing.
Smith AM, Heisler LE, Mellor J, Kaper F, Thompson MJ, Chee M, Roth FP, Giaever G, Nislow C. Smith AM, et al. Genome Res. 2009 Oct;19(10):1836-42. doi: 10.1101/gr.093955.109. Epub 2009 Jul 21. Genome Res. 2009. PMID: 19622793 Free PMC article.
A comprehensive platform for highly multiplexed mammalian functional genetic screens.
Ketela T, Heisler LE, Brown KR, Ammar R, Kasimer D, Surendra A, Ericson E, Blakely K, Karamboulas D, Smith AM, Durbic T, Arnoldo A, Cheung-Ong K, Koh JL, Gopal S, Cowley GS, Yang X, Grenier JK, Giaever G, Root DE, Moffat J, Nislow C. Ketela T, et al. Among authors: smith am. BMC Genomics. 2011 May 6;12:213. doi: 10.1186/1471-2164-12-213. BMC Genomics. 2011. PMID: 21548937 Free PMC article.
Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell.
Magtanong L, Ho CH, Barker SL, Jiao W, Baryshnikova A, Bahr S, Smith AM, Heisler LE, Choy JS, Kuzmin E, Andrusiak K, Kobylianski A, Li Z, Costanzo M, Basrai MA, Giaever G, Nislow C, Andrews B, Boone C. Magtanong L, et al. Among authors: smith am. Nat Biotechnol. 2011 May 15;29(6):505-11. doi: 10.1038/nbt.1855. Nat Biotechnol. 2011. PMID: 21572441 Free PMC article.
Competitive genomic screens of barcoded yeast libraries.
Smith AM, Durbic T, Oh J, Urbanus M, Proctor M, Heisler LE, Giaever G, Nislow C. Smith AM, et al. J Vis Exp. 2011 Aug 11;(54):2864. doi: 10.3791/2864. J Vis Exp. 2011. PMID: 21860376 Free PMC article.
1,988 results