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5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile.
Nawrozkij MB, Rotili D, Tarantino D, Botta G, Eremiychuk AS, Musmuca I, Ragno R, Samuele A, Zanoli S, Armand-Ugón M, Clotet-Codina I, Novakov IA, Orlinson BS, Maga G, Esté JA, Artico M, Mai A. Nawrozkij MB, et al. Among authors: maga g. J Med Chem. 2008 Aug 14;51(15):4641-52. doi: 10.1021/jm800340w. Epub 2008 Jul 17. J Med Chem. 2008. PMID: 18630898
Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity.
Campiani G, Morelli E, Fabbrini M, Nacci V, Greco G, Novellino E, Ramunno A, Maga G, Spadari S, Caliendo G, Bergamini A, Faggioli E, Uccella I, Bolacchi F, Marini S, Coletta M, Nacca A, Caccia S. Campiani G, et al. Among authors: maga g. J Med Chem. 1999 Oct 21;42(21):4462-70. doi: 10.1021/jm990150o. J Med Chem. 1999. PMID: 10543890
5-Alkyl-2-alkylamino-6-(2,6-difluorophenylalkyl)-3,4-dihydropyrimidin-4(3H)-ones, a new series of potent, broad-spectrum non-nucleoside reverse transcriptase inhibitors belonging to the DABO family.
Mai A, Artico M, Ragno R, Sbardella G, Massa S, Musiu C, Mura M, Marturana F, Cadeddu A, Maga G, La Colla P. Mai A, et al. Among authors: maga g. Bioorg Med Chem. 2005 Mar 15;13(6):2065-77. doi: 10.1016/j.bmc.2005.01.005. Bioorg Med Chem. 2005. PMID: 15727860
High potency of indolyl aryl sulfone nonnucleoside inhibitors towards drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutants is due to selective targeting of different mechanistic forms of the enzyme.
Cancio R, Silvestri R, Ragno R, Artico M, De Martino G, La Regina G, Crespan E, Zanoli S, Hübscher U, Spadari S, Maga G. Cancio R, et al. Among authors: maga g. Antimicrob Agents Chemother. 2005 Nov;49(11):4546-54. doi: 10.1128/AAC.49.11.4546-4554.2005. Antimicrob Agents Chemother. 2005. PMID: 16251294 Free PMC article.
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.
Fattorusso C, Gemma S, Butini S, Huleatt P, Catalanotti B, Persico M, De Angelis M, Fiorini I, Nacci V, Ramunno A, Rodriquez M, Greco G, Novellino E, Bergamini A, Marini S, Coletta M, Maga G, Spadari S, Campiani G. Fattorusso C, et al. Among authors: maga g. J Med Chem. 2005 Nov 17;48(23):7153-65. doi: 10.1021/jm050257d. J Med Chem. 2005. PMID: 16279773
264 results