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(9S)-9-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one, a selective and orally active neuropeptide Y Y5 receptor antagonist.
Sato N, Jitsuoka M, Shibata T, Hirohashi T, Nonoshita K, Moriya M, Haga Y, Sakuraba A, Ando M, Ohe T, Iwaasa H, Gomori A, Ishihara A, Kanatani A, Fukami T. Sato N, et al. Among authors: hirohashi t. J Med Chem. 2008 Aug 14;51(15):4765-70. doi: 10.1021/jm8003587. Epub 2008 Jul 19. J Med Chem. 2008. PMID: 18637668
Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists.
Takahashi T, Haga Y, Sakamoto T, Moriya M, Okamoto O, Nonoshita K, Shibata T, Suga T, Takahashi H, Hirohashi T, Sakuraba A, Gomori A, Iwaasa H, Ohe T, Ishihara A, Ishii Y, Kanatani A, Fukami T. Takahashi T, et al. Among authors: hirohashi t. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3511-6. doi: 10.1016/j.bmcl.2009.05.013. Epub 2009 May 9. Bioorg Med Chem Lett. 2009. PMID: 19464889
Novel orally active NPY Y5 receptor antagonists: Synthesis and structure-activity relationship of spiroindoline class compounds.
Sakamoto T, Moriya M, Tsuge H, Takahashi T, Haga Y, Nonoshita K, Okamoto O, Takahashi H, Sakuraba A, Hirohashi T, Shibata T, Kanno T, Ito J, Iwaasa H, Gomori A, Ishihara A, Fukuroda T, Kanatani A, Fukami T. Sakamoto T, et al. Among authors: hirohashi t. Bioorg Med Chem. 2009 Jul 15;17(14):5015-26. doi: 10.1016/j.bmc.2009.05.064. Epub 2009 Jun 2. Bioorg Med Chem. 2009. PMID: 19525116
Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver.
Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T, Sugiyama Y. Ito K, et al. Among authors: hirohashi t. J Biol Chem. 1998 Jan 16;273(3):1684-8. doi: 10.1074/jbc.273.3.1684. J Biol Chem. 1998. PMID: 9430713 Free article.
Previously, we cloned cDNA that may encode cMOAT from Sprague-Dawley rat liver (Ito, K., Suzuki, H., Hirohashi, T., Kume, K., Shimizu, T., and Sugiyama, Y. (1997) Am. J. Physiol. 272, G16-G22). ...
Previously, we cloned cDNA that may encode cMOAT from Sprague-Dawley rat liver (Ito, K., Suzuki, H., Hirohashi, T., Kume, K., …
Chronic intracerebroventricular administration of relaxin-3 increases body weight in rats.
Hida T, Takahashi E, Shikata K, Hirohashi T, Sawai T, Seiki T, Tanaka H, Kawai T, Ito O, Arai T, Yokoi A, Hirakawa T, Ogura H, Nagasu T, Miyamoto N, Kuromitsu J. Hida T, et al. Among authors: hirohashi t. J Recept Signal Transduct Res. 2006;26(3):147-58. doi: 10.1080/10799890600623373. J Recept Signal Transduct Res. 2006. PMID: 16777712
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