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JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes.
Dvorak Z, Vrzal R, Henklova P, Jancova P, Anzenbacherova E, Maurel P, Svecova L, Pavek P, Ehrmann J, Havlik R, Bednar P, Lemr K, Ulrichova J. Dvorak Z, et al. Among authors: jancova p. Biochem Pharmacol. 2008 Jan 15;75(2):580-8. doi: 10.1016/j.bcp.2007.09.013. Epub 2007 Sep 16. Biochem Pharmacol. 2008. PMID: 17959153
Silybin is metabolized by cytochrome P450 2C8 in vitro.
Jancová P, Anzenbacherová E, Papousková B, Lemr K, Luzná P, Veinlichová A, Anzenbacher P, Simánek V. Jancová P, et al. Drug Metab Dispos. 2007 Nov;35(11):2035-9. doi: 10.1124/dmd.107.016410. Epub 2007 Aug 1. Drug Metab Dispos. 2007. PMID: 17670841
Phase II drug metabolizing enzymes.
Jancova P, Anzenbacher P, Anzenbacherova E. Jancova P, et al. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2010 Jun;154(2):103-16. doi: 10.5507/bp.2010.017. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2010. PMID: 20668491 Review.
19 results