Chuang JL - Search Results

1

Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity.

Wynn RM, Kato M, Chuang JL, Tso SC, Li J, Chuang DT. Wynn RM, et al. Among authors: chuang jl, chuang dt. J Biol Chem. 2008 Sep 12;283(37):25305-25315. doi: 10.1074/jbc.M802249200. Epub 2008 Jul 24. J Biol Chem. 2008. PMID: 18658136 Free PMC article.

2

The C-terminal hinge region of lipoic acid-bearing domain of E2b is essential for domain interaction with branched-chain alpha-keto acid dehydrogenase kinase.

Chuang JL, Wynn RM, Chuang DT. Chuang JL, et al. Among authors: chuang dt. J Biol Chem. 2002 Oct 4;277(40):36905-8. doi: 10.1074/jbc.C200430200. Epub 2002 Aug 19. J Biol Chem. 2002. PMID: 12189132 Free article.

3

Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase: refined phosphorylation loop structure in the active site.

Wynn RM, Machius M, Chuang JL, Li J, Tomchick DR, Chuang DT. Wynn RM, et al. Among authors: chuang jl, chuang dt. J Biol Chem. 2003 Oct 31;278(44):43402-10. doi: 10.1074/jbc.M306204200. Epub 2003 Aug 5. J Biol Chem. 2003. PMID: 12902323 Free article.

4

Structural and biochemical basis for novel mutations in homozygous Israeli maple syrup urine disease patients: a proposed mechanism for the thiamin-responsive phenotype.

Chuang JL, Wynn RM, Moss CC, Song JL, Li J, Awad N, Mandel H, Chuang DT. Chuang JL, et al. Among authors: chuang dt. J Biol Chem. 2004 Apr 23;279(17):17792-800. doi: 10.1074/jbc.M313879200. Epub 2004 Jan 23. J Biol Chem. 2004. PMID: 14742428 Free article.

5

Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase.

Li J, Wynn RM, Machius M, Chuang JL, Karthikeyan S, Tomchick DR, Chuang DT. Li J, et al. Among authors: chuang jl, chuang dt. J Biol Chem. 2004 Jul 30;279(31):32968-78. doi: 10.1074/jbc.M403611200. Epub 2004 May 27. J Biol Chem. 2004. PMID: 15166214 Free article.

6

Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex.

Kato M, Chuang JL, Tso SC, Wynn RM, Chuang DT. Kato M, et al. Among authors: chuang jl, chuang dt. EMBO J. 2005 May 18;24(10):1763-74. doi: 10.1038/sj.emboj.7600663. Epub 2005 Apr 28. EMBO J. 2005. PMID: 15861126 Free PMC article.

7

Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex.

Brautigam CA, Wynn RM, Chuang JL, Machius M, Tomchick DR, Chuang DT. Brautigam CA, et al. Among authors: chuang jl, chuang dt. Structure. 2006 Mar;14(3):611-21. doi: 10.1016/j.str.2006.01.001. Epub 2006 Jan 26. Structure. 2006. PMID: 16442803 Free PMC article.

8

Structural determinants for cross-talk between pyruvate dehydrogenase kinase 3 and lipoyl domain 2 of the human pyruvate dehydrogenase complex.

Tso SC, Kato M, Chuang JL, Chuang DT. Tso SC, et al. Among authors: chuang jl, chuang dt. J Biol Chem. 2006 Sep 15;281(37):27197-204. doi: 10.1074/jbc.M604339200. Epub 2006 Jul 18. J Biol Chem. 2006. PMID: 16849321 Free article.

9

The two active sites in human branched-chain alpha-keto acid dehydrogenase operate independently without an obligatory alternating-site mechanism.

Li J, Machius M, Chuang JL, Wynn RM, Chuang DT. Li J, et al. Among authors: chuang jl, chuang dt. J Biol Chem. 2007 Apr 20;282(16):11904-13. doi: 10.1074/jbc.M610843200. Epub 2007 Feb 27. J Biol Chem. 2007. PMID: 17329260 Free article.

10

Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.

Kato M, Li J, Chuang JL, Chuang DT. Kato M, et al. Among authors: chuang jl, chuang dt. Structure. 2007 Aug;15(8):992-1004. doi: 10.1016/j.str.2007.07.001. Epub 2007 Aug 2. Structure. 2007. PMID: 17683942 Free PMC article.

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