Luo Y - Search Results

1

Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.

Lawrence HR, Pireddu R, Chen L, Luo Y, Sung SS, Szymanski AM, Yip ML, Guida WC, Sebti SM, Wu J, Lawrence NJ. Lawrence HR, et al. Among authors: luo y. J Med Chem. 2008 Aug 28;51(16):4948-56. doi: 10.1021/jm8002526. Epub 2008 Aug 5. J Med Chem. 2008. PMID: 18680359 Free PMC article.

2

Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112.

Chen L, Pernazza D, Scott LM, Lawrence HR, Ren Y, Luo Y, Wu X, Sung SS, Guida WC, Sebti SM, Lawrence NJ, Wu J. Chen L, et al. Among authors: luo y. Biochem Pharmacol. 2010 Sep 15;80(6):801-10. doi: 10.1016/j.bcp.2010.05.019. Epub 2010 May 25. Biochem Pharmacol. 2010. PMID: 20510203 Free PMC article.

3

Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors.

Lawrence HR, Kazi A, Luo Y, Kendig R, Ge Y, Jain S, Daniel K, Santiago D, Guida WC, Sebti SM. Lawrence HR, et al. Among authors: luo y. Bioorg Med Chem. 2010 Aug 1;18(15):5576-92. doi: 10.1016/j.bmc.2010.06.038. Epub 2010 Jun 18. Bioorg Med Chem. 2010. PMID: 20621484 Free PMC article.

4

Discovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors.

Ge Y, Kazi A, Marsilio F, Luo Y, Jain S, Brooks W, Daniel KG, Guida WC, Sebti SM, Lawrence HR. Ge Y, et al. Among authors: luo y. J Med Chem. 2012 Mar 8;55(5):1978-98. doi: 10.1021/jm201118h. Epub 2012 Feb 14. J Med Chem. 2012. PMID: 22220566 Free PMC article.

5

Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors.

Lawrence HR, Martin MP, Luo Y, Pireddu R, Yang H, Gevariya H, Ozcan S, Zhu JY, Kendig R, Rodriguez M, Elias R, Cheng JQ, Sebti SM, Schonbrunn E, Lawrence NJ. Lawrence HR, et al. Among authors: luo y. J Med Chem. 2012 Sep 13;55(17):7392-7416. doi: 10.1021/jm300334d. Epub 2012 Aug 30. J Med Chem. 2012. PMID: 22803810 Free PMC article.

6

Development of novel ACK1/TNK2 inhibitors using a fragment-based approach.

Lawrence HR, Mahajan K, Luo Y, Zhang D, Tindall N, Huseyin M, Gevariya H, Kazi S, Ozcan S, Mahajan NP, Lawrence NJ. Lawrence HR, et al. Among authors: luo y. J Med Chem. 2015 Mar 26;58(6):2746-63. doi: 10.1021/jm501929n. Epub 2015 Mar 17. J Med Chem. 2015. PMID: 25699576 Free PMC article.

7

A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A.

Martin MP, Zhu JY, Lawrence HR, Pireddu R, Luo Y, Alam R, Ozcan S, Sebti SM, Lawrence NJ, Schönbrunn E. Martin MP, et al. Among authors: luo y. ACS Chem Biol. 2012 Apr 20;7(4):698-706. doi: 10.1021/cb200508b. Epub 2012 Jan 27. ACS Chem Biol. 2012. PMID: 22248356 Free PMC article.

8

Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity.

Mahajan K, Challa S, Coppola D, Lawrence H, Luo Y, Gevariya H, Zhu W, Chen YA, Lawrence NJ, Mahajan NP. Mahajan K, et al. Among authors: luo y. Prostate. 2010 Sep 1;70(12):1274-85. doi: 10.1002/pros.21163. Prostate. 2010. PMID: 20623637 Free PMC article.

9

Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation.

Yang H, Lawrence HR, Kazi A, Gevariya H, Patel R, Luo Y, Rix U, Schonbrunn E, Lawrence NJ, Sebti SM. Yang H, et al. Among authors: luo y. Oncotarget. 2014 May 30;5(10):2947-61. doi: 10.18632/oncotarget.1615. Oncotarget. 2014. PMID: 24930769 Free PMC article.

10

Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting.

Sawant M, Mahajan K, Renganathan A, Weimholt C, Luo J, Kukshal V, Jez JM, Jeon MS, Zhang B, Li T, Fang B, Luo Y, Lawrence NJ, Lawrence HR, Feng FY, Mahajan NP. Sawant M, et al. Among authors: luo y, luo j. Sci Transl Med. 2022 Jun 15;14(649):eabg4132. doi: 10.1126/scitranslmed.abg4132. Epub 2022 Jun 15. Sci Transl Med. 2022. PMID: 35704598 Free PMC article.

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