Tam YK - Search Results

1

The effect of circulation lifetime and drug-to-lipid ratio of intravenously administered lipid nanoparticles on the biodistribution and immunostimulatory activity of encapsulated CpG-ODN.

Raney SG, Wilson KD, Sekirov L, Chikh G, de Jong SD, Cullis PR, Tam YK. Raney SG, et al. Among authors: tam yk. J Drug Target. 2008 Aug;16(7):564-77. doi: 10.1080/10611860802228756. J Drug Target. 2008. PMID: 18686126

2

Methods for the preparation of protein-oligonucleotide-lipid constructs.

Takasaki J, Raney SG, Chikh G, Sekirov L, Brodsky I, Tam Y, Ansell SM. Takasaki J, et al. Bioconjug Chem. 2006 Mar-Apr;17(2):451-8. doi: 10.1021/bc050052j. Bioconjug Chem. 2006. PMID: 16536477

3

Encapsulation in liposomal nanoparticles enhances the immunostimulatory, adjuvant and anti-tumor activity of subcutaneously administered CpG ODN.

de Jong S, Chikh G, Sekirov L, Raney S, Semple S, Klimuk S, Yuan N, Hope M, Cullis P, Tam Y. de Jong S, et al. Cancer Immunol Immunother. 2007 Aug;56(8):1251-64. doi: 10.1007/s00262-006-0276-x. Epub 2007 Jan 23. Cancer Immunol Immunother. 2007. PMID: 17242927 Free PMC article.

4

Effects of intravenous and subcutaneous administration on the pharmacokinetics, biodistribution, cellular uptake and immunostimulatory activity of CpG ODN encapsulated in liposomal nanoparticles.

Wilson KD, Raney SG, Sekirov L, Chikh G, deJong SD, Cullis PR, Tam YK. Wilson KD, et al. Among authors: tam yk. Int Immunopharmacol. 2007 Aug;7(8):1064-75. doi: 10.1016/j.intimp.2007.04.002. Epub 2007 May 2. Int Immunopharmacol. 2007. PMID: 17570323

5

The combination of stabilized plasmid lipid particles and lipid nanoparticle encapsulated CpG containing oligodeoxynucleotides as a systemic genetic vaccine.

Wilson KD, de Jong SD, Kazem M, Lall R, Hope MJ, Cullis PR, Tam YK. Wilson KD, et al. Among authors: tam yk. J Gene Med. 2009 Jan;11(1):14-25. doi: 10.1002/jgm.1267. J Gene Med. 2009. PMID: 19003796

6

Lipid-based delivery of CpG oligonucleotides enhances immunotherapeutic efficacy.

Wilson KD, de Jong SD, Tam YK. Wilson KD, et al. Among authors: tam yk. Adv Drug Deliv Rev. 2009 Mar 28;61(3):233-42. doi: 10.1016/j.addr.2008.12.014. Epub 2009 Feb 13. Adv Drug Deliv Rev. 2009. PMID: 19232375 Review.

7

Synthetic methylated CpG ODNs are potent in vivo adjuvants when delivered in liposomal nanoparticles.

Chikh G, de Jong SD, Sekirov L, Raney SG, Kazem M, Wilson KD, Cullis PR, Dutz JP, Tam YK. Chikh G, et al. Among authors: tam yk. Int Immunol. 2009 Jul;21(7):757-67. doi: 10.1093/intimm/dxp044. Epub 2009 Jun 5. Int Immunol. 2009. PMID: 19502586

8

Rational design of cationic lipids for siRNA delivery.

Semple SC, Akinc A, Chen J, Sandhu AP, Mui BL, Cho CK, Sah DW, Stebbing D, Crosley EJ, Yaworski E, Hafez IM, Dorkin JR, Qin J, Lam K, Rajeev KG, Wong KF, Jeffs LB, Nechev L, Eisenhardt ML, Jayaraman M, Kazem M, Maier MA, Srinivasulu M, Weinstein MJ, Chen Q, Alvarez R, Barros SA, De S, Klimuk SK, Borland T, Kosovrasti V, Cantley WL, Tam YK, Manoharan M, Ciufolini MA, Tracy MA, de Fougerolles A, MacLachlan I, Cullis PR, Madden TD, Hope MJ. Semple SC, et al. Among authors: tam yk. Nat Biotechnol. 2010 Feb;28(2):172-6. doi: 10.1038/nbt.1602. Epub 2010 Jan 17. Nat Biotechnol. 2010. PMID: 20081866

9

The immunostimulatory activity of unmethylated and methylated CpG oligodeoxynucleotide is dependent on their ability to colocalize with TLR9 in late endosomes.

de Jong SD, Basha G, Wilson KD, Kazem M, Cullis P, Jefferies W, Tam Y. de Jong SD, et al. J Immunol. 2010 Jun 1;184(11):6092-102. doi: 10.4049/jimmunol.0802442. Epub 2010 Apr 28. J Immunol. 2010. PMID: 20427776

10

Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells.

Basha G, Novobrantseva TI, Rosin N, Tam YY, Hafez IM, Wong MK, Sugo T, Ruda VM, Qin J, Klebanov B, Ciufolini M, Akinc A, Tam YK, Hope MJ, Cullis PR. Basha G, et al. Among authors: tam yk, tam yy. Mol Ther. 2011 Dec;19(12):2186-200. doi: 10.1038/mt.2011.190. Epub 2011 Oct 4. Mol Ther. 2011. PMID: 21971424 Free PMC article.

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