Carlier PR - Search Results

1

Antidepressant-like pharmacological profile of a novel triple reuptake inhibitor, (1S,2S)-3-(methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS).

Liang Y, Shaw AM, Boules M, Briody S, Robinson J, Oliveros A, Blazar E, Williams K, Zhang Y, Carlier PR, Richelson E. Liang Y, et al. Among authors: carlier pr. J Pharmacol Exp Ther. 2008 Nov;327(2):573-83. doi: 10.1124/jpet.108.143610. Epub 2008 Aug 8. J Pharmacol Exp Ther. 2008. PMID: 18689611

2

Antidepressant-like effects of novel triple reuptake inhibitors, PRC025 and PRC050.

Shaw AM, Boules M, Zhang Y, Williams K, Robinson J, Carlier PR, Richelson E. Shaw AM, et al. Among authors: carlier pr. Eur J Pharmacol. 2007 Jan 19;555(1):30-6. doi: 10.1016/j.ejphar.2006.10.004. Epub 2006 Oct 17. Eur J Pharmacol. 2007. PMID: 17109850

3

The first enantioenriched metalated nitrile possessing macroscopic configurational stability.

Carlier PR, Zhang Y. Carlier PR, et al. Org Lett. 2007 Mar 29;9(7):1319-22. doi: 10.1021/ol070149g. Epub 2007 Mar 10. Org Lett. 2007. PMID: 17348666

4

Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group.

Carlier PR, Lo MM, Lo PC, Richelson E, Tatsumi M, Reynolds IJ, Sharma TA. Carlier PR, et al. Bioorg Med Chem Lett. 1998 Mar 3;8(5):487-92. doi: 10.1016/s0960-894x(98)00062-6. Bioorg Med Chem Lett. 1998. PMID: 9871604

5

Effect of 2,6-disubstituted aryl groups on acyclic conformation: preference for an antiperiplanar orientation of the geminal and vicinal hydrogens.

Carlier PR, Zhang Y, Slebodnick C, Lo MM, Williams ID. Carlier PR, et al. J Org Chem. 2006 Nov 10;71(23):8835-41. doi: 10.1021/jo061495z. J Org Chem. 2006. PMID: 17081013

6

Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities.

Han YF, Li CP, Chow E, Wang H, Pang YP, Carlier PR. Han YF, et al. Among authors: carlier pr. Bioorg Med Chem. 1999 Nov;7(11):2569-75. doi: 10.1016/s0968-0896(99)00178-9. Bioorg Med Chem. 1999. PMID: 10632067

7

Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis.

Carlier PR, Han YF, Chow ES, Li CP, Wang H, Lieu TX, Wong HS, Pang YP. Carlier PR, et al. Bioorg Med Chem. 1999 Feb;7(2):351-7. doi: 10.1016/s0968-0896(98)00213-2. Bioorg Med Chem. 1999. PMID: 10218828

8

Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.

Carlier PR, Du DM, Han Y, Liu J, Pang YP. Carlier PR, et al. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2335-8. doi: 10.1016/s0960-894x(99)00396-0. Bioorg Med Chem Lett. 1999. PMID: 10476864

9

Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions.

Carlier PR, Chow ES, Han Y, Liu J, El Yazal J, Pang YP. Carlier PR, et al. J Med Chem. 1999 Oct 7;42(20):4225-31. doi: 10.1021/jm990224w. J Med Chem. 1999. PMID: 10514292

10

Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase.

Hartsel JA, Wong DM, Mutunga JM, Ma M, Anderson TD, Wysinski A, Islam R, Wong EA, Paulson SL, Li J, Lam PC, Totrov MM, Bloomquist JR, Carlier PR. Hartsel JA, et al. Among authors: carlier pr. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4593-8. doi: 10.1016/j.bmcl.2012.05.103. Epub 2012 Jun 6. Bioorg Med Chem Lett. 2012. PMID: 22738634 Free PMC article.

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