Jørgensen AS - Search Results

1

Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor.

Kodra JT, Jørgensen AS, Andersen B, Behrens C, Brand CL, Christensen IT, Guldbrandt M, Jeppesen CB, Knudsen LB, Madsen P, Nishimura E, Sams C, Sidelmann UG, Pedersen RA, Lynn FC, Lau J. Kodra JT, et al. Among authors: jorgensen as. J Med Chem. 2008 Sep 11;51(17):5387-96. doi: 10.1021/jm7015599. Epub 2008 Aug 16. J Med Chem. 2008. PMID: 18707090

2

Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties.

Madsen P, Kodra JT, Behrens C, Nishimura E, Jeppesen CB, Pridal L, Andersen B, Knudsen LB, Valcarce-Aspegren C, Guldbrandt M, Christensen IT, Jørgensen AS, Ynddal L, Brand CL, Bagger MA, Lau J. Madsen P, et al. Among authors: jorgensen as. J Med Chem. 2009 May 14;52(9):2989-3000. doi: 10.1021/jm8016249. J Med Chem. 2009. PMID: 19385613

3

Small-molecule agonists for the glucagon-like peptide 1 receptor.

Knudsen LB, Kiel D, Teng M, Behrens C, Bhumralkar D, Kodra JT, Holst JJ, Jeppesen CB, Johnson MD, de Jong JC, Jorgensen AS, Kercher T, Kostrowicki J, Madsen P, Olesen PH, Petersen JS, Poulsen F, Sidelmann UG, Sturis J, Truesdale L, May J, Lau J. Knudsen LB, et al. Among authors: jorgensen as. Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):937-42. doi: 10.1073/pnas.0605701104. Epub 2007 Jan 9. Proc Natl Acad Sci U S A. 2007. PMID: 17213325 Free PMC article.

4

Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor.

Teng M, Johnson MD, Thomas C, Kiel D, Lakis JN, Kercher T, Aytes S, Kostrowicki J, Bhumralkar D, Truesdale L, May J, Sidelman U, Kodra JT, Jørgensen AS, Olesen PH, de Jong JC, Madsen P, Behrens C, Pettersson I, Knudsen LB, Holst JJ, Lau J. Teng M, et al. Among authors: jorgensen as. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5472-8. doi: 10.1016/j.bmcl.2007.06.086. Epub 2007 Jul 4. Bioorg Med Chem Lett. 2007. PMID: 17827014

5

The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate.

Andersen KE, Braestrup C, Grønwald FC, Jørgensen AS, Nielsen EB, Sonnewald U, Sørensen PO, Suzdak PD, Knutsen LJ. Andersen KE, et al. Among authors: jorgensen as. J Med Chem. 1993 Jun 11;36(12):1716-25. doi: 10.1021/jm00064a005. J Med Chem. 1993. PMID: 8510100

6

Synthesis and biological evaluation of novel thio-substituted chromanes as high-affinity partial agonists for the estrogen receptor.

Christiansen LB, Wenckens M, Bury PS, Gissel B, Hansen BS, Thorpe SM, Jacobsen P, Kanstrup A, Jørgensen AS, Naerum L, Wassermann K. Christiansen LB, et al. Among authors: jorgensen as. Bioorg Med Chem Lett. 2002 Jan 7;12(1):17-9. doi: 10.1016/s0960-894x(01)00679-5. Bioorg Med Chem Lett. 2002. PMID: 11738564

7

Synthesis and estrogen receptor binding affinities of novel pyrrolo[2,1,5-cd]indolizine derivatives.

Jørgensen AS, Jacobsen P, Christiansen LB, Bury PS, Kanstrup A, Thorpe SM, Naerum L, Wassermann K. Jørgensen AS, et al. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2383-6. doi: 10.1016/s0960-894x(00)00474-1. Bioorg Med Chem Lett. 2000. PMID: 11055361

8

Synthesis and pharmacological evaluation of novel cis-3,4-diaryl-hydroxychromanes as high affinity partial agonists for the estrogen receptor.

Bury PS, Christiansen LB, Jacobsen P, Jørgensen AS, Kanstrup A, Naerum L, Bain S, Fledelius C, Gissel B, Hansen BS, Korsgaard N, Thorpe SM, Wassermann K. Bury PS, et al. Among authors: jorgensen as. Bioorg Med Chem. 2002 Jan;10(1):125-45. doi: 10.1016/s0968-0896(01)00257-7. Bioorg Med Chem. 2002. PMID: 11738615

9

Synthesis and pharmacology of a novel pyrrolo[2,1,5-cd] indolizine (NNC 45-0095), a high affinity non-steroidal agonist for the estrogen receptor.

Jørgensen AS, Jacobsen P, Christiansen LB, Bury PS, Kanstrup A, Thorpe SM, Bain S, Naerum L, Wassermann K. Jørgensen AS, et al. Bioorg Med Chem Lett. 2000 Feb 21;10(4):399-402. doi: 10.1016/s0960-894x(00)00015-9. Bioorg Med Chem Lett. 2000. PMID: 10714509

10

A laboratory feasibility study using a computer algorithm for anastomosis segmentation of epicardial ultrasonography images from distal coronary artery bypass anastomoses.

Jørgensen AS, Andersen MS, Østergaard LR, Schmidt SE, Nøhr D, Andreasen JJ. Jørgensen AS, et al. J Cardiothorac Surg. 2025 Jan 6;20(1):34. doi: 10.1186/s13019-024-03187-8. J Cardiothorac Surg. 2025. PMID: 39762954 Free PMC article.

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