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Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor.
Kodra JT, Jørgensen AS, Andersen B, Behrens C, Brand CL, Christensen IT, Guldbrandt M, Jeppesen CB, Knudsen LB, Madsen P, Nishimura E, Sams C, Sidelmann UG, Pedersen RA, Lynn FC, Lau J. Kodra JT, et al. Among authors: nishimura e. J Med Chem. 2008 Sep 11;51(17):5387-96. doi: 10.1021/jm7015599. Epub 2008 Aug 16. J Med Chem. 2008. PMID: 18707090
Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice.
Gelling RW, Du XQ, Dichmann DS, Romer J, Huang H, Cui L, Obici S, Tang B, Holst JJ, Fledelius C, Johansen PB, Rossetti L, Jelicks LA, Serup P, Nishimura E, Charron MJ. Gelling RW, et al. Among authors: nishimura e. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1438-43. doi: 10.1073/pnas.0237106100. Epub 2003 Jan 24. Proc Natl Acad Sci U S A. 2003. PMID: 12552113 Free PMC article.
288 results