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Page 1
Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor.
Kodra JT, Jørgensen AS, Andersen B, Behrens C, Brand CL, Christensen IT, Guldbrandt M, Jeppesen CB, Knudsen LB, Madsen P, Nishimura E, Sams C, Sidelmann UG, Pedersen RA, Lynn FC, Lau J. Kodra JT, et al. Among authors: sams c. J Med Chem. 2008 Sep 11;51(17):5387-96. doi: 10.1021/jm7015599. Epub 2008 Aug 16. J Med Chem. 2008. PMID: 18707090
Human glucagon receptor antagonists based on alkylidene hydrazides.
Ling A, Plewe M, Gonzalez J, Madsen P, Sams CK, Lau J, Gregor V, Murphy D, Teston K, Kuki A, Shi S, Truesdale L, Kiel D, May J, Lakis J, Anderes K, Iatsimirskaia E, Sidelmann UG, Knudsen LB, Brand CL, Polinsky A. Ling A, et al. Bioorg Med Chem Lett. 2002 Feb 25;12(4):663-6. doi: 10.1016/s0960-894x(01)00819-8. Bioorg Med Chem Lett. 2002. PMID: 11844695
Optimization of alkylidene hydrazide based human glucagon receptor antagonists. Discovery of the highly potent and orally available 3-cyano-4-hydroxybenzoic acid [1-(2,3,5,6-tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide.
Madsen P, Ling A, Plewe M, Sams CK, Knudsen LB, Sidelmann UG, Ynddal L, Brand CL, Andersen B, Murphy D, Teng M, Truesdale L, Kiel D, May J, Kuki A, Shi S, Johnson MD, Teston KA, Feng J, Lakis J, Anderes K, Gregor V, Lau J. Madsen P, et al. J Med Chem. 2002 Dec 19;45(26):5755-75. doi: 10.1021/jm0208572. J Med Chem. 2002. PMID: 12477359
Diastereoselective and Enantioselective Synthesis of α-p-Methoxyphenoxy-β-Lactones: Dependence on the Stereoelectronic Properties of the β-Hydroxy-α-p-Methoxyphenoxycarboxylic Acid Precursors.
Witte JM, Service J, Addo MA, Semakieh B, Collins E, Sams C, Dorsey TR, Garrelts E, Blumenshine CA, Cooper T, Martinez M, Hamaker CG, Ferrence GM, Hitchcock SR. Witte JM, et al. Among authors: sams c. J Org Chem. 2022 Aug 5;87(15):9619-9634. doi: 10.1021/acs.joc.2c00608. Epub 2022 Jul 21. J Org Chem. 2022. PMID: 35862509
Severe Spaceflight-Associated Neuro-Ocular Syndrome in an Astronaut With 2 Predisposing Factors.
Brunstetter TJ, Zwart SR, Brandt K, Brown DM, Clemett SJ, Douglas GL, Gibson CR, Laurie SS, Lee AG, Macias BR, Mader TH, Mason SS, Meir JU, Morgan AR, Nelman M, Patel N, Sams C, Suresh R, Tarver W, Tsung A, Van Baalen MG, Smith SM. Brunstetter TJ, et al. Among authors: sams c. JAMA Ophthalmol. 2024 Sep 1;142(9):808-817. doi: 10.1001/jamaophthalmol.2024.2385. JAMA Ophthalmol. 2024. PMID: 39052244
Diastereoselective Synthesis of the HIV Protease Inhibitor Darunavir and Related Derivatives via a Titanium Tetrachloride-Mediated Asymmetric Glycolate Aldol Addition Reaction.
Witte JM, Ayim E, Sams CJ, Service JB, Kant CC, Bambalas L, Wright D, Carter A, Moran K, Rohrig IG, Ferrence GM, Hitchcock SR. Witte JM, et al. Among authors: sams cj. J Org Chem. 2024 Jul 5;89(13):9569-9585. doi: 10.1021/acs.joc.4c01057. Epub 2024 Jun 25. J Org Chem. 2024. PMID: 38916048 Free PMC article.
199 results