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Distinct malaria parasite sporozoites reveal transcriptional changes that cause differential tissue infection competence in the mosquito vector and mammalian host.
Mikolajczak SA, Silva-Rivera H, Peng X, Tarun AS, Camargo N, Jacobs-Lorena V, Daly TM, Bergman LW, de la Vega P, Williams J, Aly AS, Kappe SH. Mikolajczak SA, et al. Among authors: williams j. Mol Cell Biol. 2008 Oct;28(20):6196-207. doi: 10.1128/MCB.00553-08. Epub 2008 Aug 18. Mol Cell Biol. 2008. PMID: 18710954 Free PMC article.
Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design.
VanBuskirk KM, O'Neill MT, De La Vega P, Maier AG, Krzych U, Williams J, Dowler MG, Sacci JB Jr, Kangwanrangsan N, Tsuboi T, Kneteman NM, Heppner DG Jr, Murdock BA, Mikolajczak SA, Aly AS, Cowman AF, Kappe SH. VanBuskirk KM, et al. Among authors: williams j. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13004-9. doi: 10.1073/pnas.0906387106. Epub 2009 Jul 22. Proc Natl Acad Sci U S A. 2009. PMID: 19625622 Free PMC article.
First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers.
Spring M, Murphy J, Nielsen R, Dowler M, Bennett JW, Zarling S, Williams J, de la Vega P, Ware L, Komisar J, Polhemus M, Richie TL, Epstein J, Tamminga C, Chuang I, Richie N, O'Neil M, Heppner DG, Healer J, O'Neill M, Smithers H, Finney OC, Mikolajczak SA, Wang R, Cowman A, Ockenhouse C, Krzych U, Kappe SH. Spring M, et al. Among authors: williams j. Vaccine. 2013 Oct 9;31(43):4975-83. doi: 10.1016/j.vaccine.2013.08.007. Epub 2013 Sep 8. Vaccine. 2013. PMID: 24029408 Clinical Trial.
Evidence of blood stage efficacy with a virosomal malaria vaccine in a phase IIa clinical trial.
Thompson FM, Porter DW, Okitsu SL, Westerfeld N, Vogel D, Todryk S, Poulton I, Correa S, Hutchings C, Berthoud T, Dunachie S, Andrews L, Williams JL, Sinden R, Gilbert SC, Pluschke G, Zurbriggen R, Hill AV. Thompson FM, et al. PLoS One. 2008 Jan 30;3(1):e1493. doi: 10.1371/journal.pone.0001493. PLoS One. 2008. PMID: 18231580 Free PMC article. Clinical Trial.
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