Ostrov DA - Search Results

1

Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth.

Sayyah J, Magis A, Ostrov DA, Allan RW, Braylan RC, Sayeski PP. Sayyah J, et al. Among authors: ostrov da. Mol Cancer Ther. 2008 Aug;7(8):2308-18. doi: 10.1158/1535-7163.MCT-08-0279. Mol Cancer Ther. 2008. PMID: 18723478 Free PMC article.

2

Ancestral origins are associated with SARS-CoV-2 susceptibility and protection in a Florida patient population.

Shen Y, Khatri B, Rananaware S, Li D, Ostrov DA, Jain PK, Lessard CJ, Nguyen CQ. Shen Y, et al. Among authors: ostrov da. PLoS One. 2023 Jan 17;18(1):e0276700. doi: 10.1371/journal.pone.0276700. eCollection 2023. PLoS One. 2023. PMID: 36649279 Free PMC article.

3

Jak2 tyrosine kinase residues glutamic acid 1024 and arginine 1113 form a hydrogen bond interaction that is essential for Jak-STAT signal transduction.

Sandberg EM, VonDerLinden D, Ostrov DA, Sayeski PP. Sandberg EM, et al. Among authors: ostrov da. Mol Cell Biochem. 2004 Oct;265(1-2):161-9. doi: 10.1023/b:mcbi.0000044393.67980.99. Mol Cell Biochem. 2004. PMID: 15543946

4

Identification of 1,2,3,4,5,6-hexabromocyclohexane as a small molecule inhibitor of jak2 tyrosine kinase autophosphorylation [correction of autophophorylation].

Sandberg EM, Ma X, He K, Frank SJ, Ostrov DA, Sayeski PP. Sandberg EM, et al. Among authors: ostrov da. J Med Chem. 2005 Apr 7;48(7):2526-33. doi: 10.1021/jm049470k. J Med Chem. 2005. PMID: 15801842

5

The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT1 receptor.

Godeny MD, Sayyah J, VonDerLinden D, Johns M, Ostrov DA, Caldwell-Busby J, Sayeski PP. Godeny MD, et al. Among authors: ostrov da. Cell Signal. 2007 Mar;19(3):600-9. doi: 10.1016/j.cellsig.2006.08.010. Epub 2006 Sep 1. Cell Signal. 2007. PMID: 17027227

6

Crystallization and X-ray diffraction analysis of a novel immune-type receptor from Ictalurus punctatus and phasing by selenium anomalous dispersion methods.

Ostrov DA, Hernández Prada JA, Haire RN, Cannon JP, Magis AT, Bailey K, Litman GW. Ostrov DA, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt 12):1035-7. doi: 10.1107/S1744309107054231. Epub 2007 Nov 21. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007. PMID: 18084086 Free PMC article.

7

Crystallization of the focal adhesion kinase targeting (FAT) domain in a primitive orthorhombic space group.

Magis AT, Bailey KM, Kurenova EV, Hernández Prada JA, Cance WG, Ostrov DA. Magis AT, et al. Among authors: ostrov da. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt 6):564-6. doi: 10.1107/S1744309108011421. Epub 2008 May 30. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008. PMID: 18540077 Free PMC article.

8

Identification of tyrosine 972 as a novel site of Jak2 tyrosine kinase phosphorylation and its role in Jak2 activation.

McDoom I, Ma X, Kirabo A, Lee KY, Ostrov DA, Sayeski PP. McDoom I, et al. Among authors: ostrov da. Biochemistry. 2008 Aug 12;47(32):8326-34. doi: 10.1021/bi800867d. Epub 2008 Jul 18. Biochemistry. 2008. PMID: 18636744 Free PMC article.

9

A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition.

Cannon JP, Haire RN, Magis AT, Eason DD, Winfrey KN, Hernandez Prada JA, Bailey KM, Jakoncic J, Litman GW, Ostrov DA. Cannon JP, et al. Among authors: ostrov da. Immunity. 2008 Aug 15;29(2):228-37. doi: 10.1016/j.immuni.2008.05.018. Epub 2008 Jul 31. Immunity. 2008. PMID: 18674935 Free PMC article.

10

A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth.

Golubovskaya VM, Nyberg C, Zheng M, Kweh F, Magis A, Ostrov D, Cance WG. Golubovskaya VM, et al. J Med Chem. 2008 Dec 11;51(23):7405-16. doi: 10.1021/jm800483v. J Med Chem. 2008. PMID: 18989950 Free PMC article.

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