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Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation.
Jeganathan S, Hascher A, Chinnathambi S, Biernat J, Mandelkow EM, Mandelkow E. Jeganathan S, et al. Among authors: mandelkow em, mandelkow e. J Biol Chem. 2008 Nov 14;283(46):32066-76. doi: 10.1074/jbc.M805300200. Epub 2008 Aug 25. J Biol Chem. 2008. PMID: 18725412 Free article.
In solution, Tau adopts a "paperclip" conformation, whereby the N- and C-terminal domains approach each other and the repeat domain ( Jeganathan, S., von Bergen, M., Brutlach, H., Steinhoff, H. J., and Mandelkow, E. (2006) Biochemistry 45, 2283-2293 ). In AD, Tau is …
In solution, Tau adopts a "paperclip" conformation, whereby the N- and C-terminal domains approach each other and the repeat domain ( Jegana …
Rhodanine-based tau aggregation inhibitors in cell models of tauopathy.
Bulic B, Pickhardt M, Khlistunova I, Biernat J, Mandelkow EM, Mandelkow E, Waldmann H. Bulic B, et al. Among authors: mandelkow em, mandelkow e. Angew Chem Int Ed Engl. 2007;46(48):9215-9. doi: 10.1002/anie.200704051. Angew Chem Int Ed Engl. 2007. PMID: 17985339 No abstract available.
The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.
Mocanu MM, Nissen A, Eckermann K, Khlistunova I, Biernat J, Drexler D, Petrova O, Schönig K, Bujard H, Mandelkow E, Zhou L, Rune G, Mandelkow EM. Mocanu MM, et al. Among authors: mandelkow em, mandelkow e. J Neurosci. 2008 Jan 16;28(3):737-48. doi: 10.1523/JNEUROSCI.2824-07.2008. J Neurosci. 2008. PMID: 18199773 Free PMC article.
Inhibition of tau aggregation in cell models of tauopathy.
Khlistunova I, Pickhardt M, Biernat J, Wang Y, Mandelkow EM, Mandelkow E. Khlistunova I, et al. Among authors: mandelkow em, mandelkow e. Curr Alzheimer Res. 2007 Dec;4(5):544-6. doi: 10.2174/156720507783018307. Curr Alzheimer Res. 2007. PMID: 18220518 Review.
The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments.
Jeganathan S, von Bergen M, Mandelkow EM, Mandelkow E. Jeganathan S, et al. Among authors: mandelkow em, mandelkow e. Biochemistry. 2008 Oct 7;47(40):10526-39. doi: 10.1021/bi800783d. Epub 2008 Sep 11. Biochemistry. 2008. PMID: 18783251
C., von Bergen, M., Biernat, J., Seidel, K., Griesinger, C., Mandelkow, E., and Baldus, M. (2008) Characterization of Alzheimer's-like paired helical filaments from the core domain of tau protein using solid-state NMR spectroscopy....
C., von Bergen, M., Biernat, J., Seidel, K., Griesinger, C., Mandelkow, E., and Baldus, M. (2008) Characterization of Alzheime …
370 results