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Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.
Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, Kaether C, Zheng H, Ghetti B, Haass C, Steiner H. Moehlmann T, et al. Among authors: winkler e. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8025-30. doi: 10.1073/pnas.112686799. Epub 2002 Jun 4. Proc Natl Acad Sci U S A. 2002. PMID: 12048239 Free PMC article.
Reconstitution of gamma-secretase activity.
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C. Edbauer D, et al. Among authors: winkler e. Nat Cell Biol. 2003 May;5(5):486-8. doi: 10.1038/ncb960. Nat Cell Biol. 2003. PMID: 12679784
865 results