Warmuth M - Search Results

1

Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation.

Dierks C, Beigi R, Guo GR, Zirlik K, Stegert MR, Manley P, Trussell C, Schmitt-Graeff A, Landwerlin K, Veelken H, Warmuth M. Dierks C, et al. Among authors: warmuth m. Cancer Cell. 2008 Sep 9;14(3):238-49. doi: 10.1016/j.ccr.2008.08.003. Cancer Cell. 2008. PMID: 18772113 Free article.

2

Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL.

Decker S, Zirlik K, Djebatchie L, Hartmann D, Ihorst G, Schmitt-Graeff A, Herchenbach D, Jumaa H, Warmuth M, Veelken H, Dierks C. Decker S, et al. Among authors: warmuth m. Blood. 2012 Jan 26;119(4):997-1007. doi: 10.1182/blood-2011-06-359075. Epub 2011 Nov 30. Blood. 2012. PMID: 22130798 Free article.

3

Essential role of stromally induced hedgehog signaling in B-cell malignancies.

Dierks C, Grbic J, Zirlik K, Beigi R, Englund NP, Guo GR, Veelken H, Engelhardt M, Mertelsmann R, Kelleher JF, Schultz P, Warmuth M. Dierks C, et al. Among authors: warmuth m. Nat Med. 2007 Aug;13(8):944-51. doi: 10.1038/nm1614. Epub 2007 Jul 15. Nat Med. 2007. PMID: 17632527

4

The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease.

Dierks C, Adrian F, Fisch P, Ma H, Maurer H, Herchenbach D, Forster CU, Sprissler C, Liu G, Rottmann S, Guo GR, Katja Z, Veelken H, Warmuth M. Dierks C, et al. Among authors: warmuth m. Cancer Res. 2010 Aug 1;70(15):6193-204. doi: 10.1158/0008-5472.CAN-08-3719. Cancer Res. 2010. PMID: 20670954

5

Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.

Zhang J, Adrián FJ, Jahnke W, Cowan-Jacob SW, Li AG, Iacob RE, Sim T, Powers J, Dierks C, Sun F, Guo GR, Ding Q, Okram B, Choi Y, Wojciechowski A, Deng X, Liu G, Fendrich G, Strauss A, Vajpai N, Grzesiek S, Tuntland T, Liu Y, Bursulaya B, Azam M, Manley PW, Engen JR, Daley GQ, Warmuth M, Gray NS. Zhang J, et al. Among authors: warmuth m. Nature. 2010 Jan 28;463(7280):501-6. doi: 10.1038/nature08675. Epub 2010 Jan 13. Nature. 2010. PMID: 20072125 Free PMC article.

6

Dual-specific Src and Abl kinase inhibitors, PP1 and CGP76030, inhibit growth and survival of cells expressing imatinib mesylate-resistant Bcr-Abl kinases.

Warmuth M, Simon N, Mitina O, Mathes R, Fabbro D, Manley PW, Buchdunger E, Forster K, Moarefi I, Hallek M. Warmuth M, et al. Blood. 2003 Jan 15;101(2):664-72. doi: 10.1182/blood-2002-01-0288. Epub 2002 Sep 5. Blood. 2003. PMID: 12393636 Free article.

7

Hedgehog pathway activation in chronic myeloid leukemia.

Jagani Z, Dorsch M, Warmuth M. Jagani Z, et al. Among authors: warmuth m. Cell Cycle. 2010 Sep 1;9(17):3449-56. doi: 10.4161/cc.9.17.12945. Cell Cycle. 2010. PMID: 20928937 Review.

8

A type-II kinase inhibitor capable of inhibiting the T315I "gatekeeper" mutant of Bcr-Abl.

Choi HG, Ren P, Adrian F, Sun F, Lee HS, Wang X, Ding Q, Zhang G, Xie Y, Zhang J, Liu Y, Tuntland T, Warmuth M, Manley PW, Mestan J, Gray NS, Sim T. Choi HG, et al. Among authors: warmuth m. J Med Chem. 2010 Aug 12;53(15):5439-48. doi: 10.1021/jm901808w. J Med Chem. 2010. PMID: 20604564 Free PMC article.

9

Allosteric inhibition of BCR-ABL.

Hassan AQ, Sharma SV, Warmuth M. Hassan AQ, et al. Among authors: warmuth m. Cell Cycle. 2010 Sep 15;9(18):3710-4. doi: 10.4161/cc.9.18.13232. Epub 2010 Sep 3. Cell Cycle. 2010. PMID: 20930519 Review.

10

Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1.

Schoepfer J, Jahnke W, Berellini G, Buonamici S, Cotesta S, Cowan-Jacob SW, Dodd S, Drueckes P, Fabbro D, Gabriel T, Groell JM, Grotzfeld RM, Hassan AQ, Henry C, Iyer V, Jones D, Lombardo F, Loo A, Manley PW, Pellé X, Rummel G, Salem B, Warmuth M, Wylie AA, Zoller T, Marzinzik AL, Furet P. Schoepfer J, et al. Among authors: warmuth m. J Med Chem. 2018 Sep 27;61(18):8120-8135. doi: 10.1021/acs.jmedchem.8b01040. Epub 2018 Sep 7. J Med Chem. 2018. PMID: 30137981

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