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High-resolution structures of Trypanosoma brucei pteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug target.
Dawson A, Tulloch LB, Barrack KL, Hunter WN. Dawson A, et al. Among authors: tulloch lb. Acta Crystallogr D Biol Crystallogr. 2010 Dec;66(Pt 12):1334-40. doi: 10.1107/S0907444910040886. Epub 2010 Nov 16. Acta Crystallogr D Biol Crystallogr. 2010. PMID: 21123874 Free PMC article.
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development.
Cavazzuti A, Paglietti G, Hunter WN, Gamarro F, Piras S, Loriga M, Allecca S, Corona P, McLuskey K, Tulloch L, Gibellini F, Ferrari S, Costi MP. Cavazzuti A, et al. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1448-53. doi: 10.1073/pnas.0704384105. Epub 2008 Feb 1. Proc Natl Acad Sci U S A. 2008. PMID: 18245389 Free PMC article.
28 results