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The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments.
Jeganathan S, von Bergen M, Mandelkow EM, Mandelkow E. Jeganathan S, et al. Among authors: mandelkow em, mandelkow e. Biochemistry. 2008 Oct 7;47(40):10526-39. doi: 10.1021/bi800783d. Epub 2008 Sep 11. Biochemistry. 2008. PMID: 18783251
Partial disaggregation of Tau filaments at extreme pH values monitored by CD and EM indicate the importance of salt bridges in filament formation. In contrast, Tau filaments are remarkably resistant to high temperature and high ionic strength. ...C., von Bergen, M., Bierna …
Partial disaggregation of Tau filaments at extreme pH values monitored by CD and EM indicate the importance of salt bridges in filame …
Rhodanine-based tau aggregation inhibitors in cell models of tauopathy.
Bulic B, Pickhardt M, Khlistunova I, Biernat J, Mandelkow EM, Mandelkow E, Waldmann H. Bulic B, et al. Among authors: mandelkow em, mandelkow e. Angew Chem Int Ed Engl. 2007;46(48):9215-9. doi: 10.1002/anie.200704051. Angew Chem Int Ed Engl. 2007. PMID: 17985339 No abstract available.
The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.
Mocanu MM, Nissen A, Eckermann K, Khlistunova I, Biernat J, Drexler D, Petrova O, Schönig K, Bujard H, Mandelkow E, Zhou L, Rune G, Mandelkow EM. Mocanu MM, et al. Among authors: mandelkow em, mandelkow e. J Neurosci. 2008 Jan 16;28(3):737-48. doi: 10.1523/JNEUROSCI.2824-07.2008. J Neurosci. 2008. PMID: 18199773 Free PMC article.
Inhibition of tau aggregation in cell models of tauopathy.
Khlistunova I, Pickhardt M, Biernat J, Wang Y, Mandelkow EM, Mandelkow E. Khlistunova I, et al. Among authors: mandelkow em, mandelkow e. Curr Alzheimer Res. 2007 Dec;4(5):544-6. doi: 10.2174/156720507783018307. Curr Alzheimer Res. 2007. PMID: 18220518 Review.
230 results