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TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.
Vince JE, Pantaki D, Feltham R, Mace PD, Cordier SM, Schmukle AC, Davidson AJ, Callus BA, Wong WW, Gentle IE, Carter H, Lee EF, Walczak H, Day CL, Vaux DL, Silke J. Vince JE, et al. Among authors: mace pd. J Biol Chem. 2009 Dec 18;284(51):35906-15. doi: 10.1074/jbc.M109.072256. J Biol Chem. 2009. PMID: 19815541 Free PMC article.
Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.
Feltham R, Moulin M, Vince JE, Mace PD, Wong WW, Anderton H, Day CL, Vaux DL, Silke J. Feltham R, et al. Among authors: mace pd. J Biol Chem. 2010 Jun 4;285(23):17525-36. doi: 10.1074/jbc.M109.087635. Epub 2010 Mar 30. J Biol Chem. 2010. PMID: 20356846 Free PMC article.
Asymmetric recruitment of cIAPs by TRAF2.
Mace PD, Smits C, Vaux DL, Silke J, Day CL. Mace PD, et al. J Mol Biol. 2010 Jul 2;400(1):8-15. doi: 10.1016/j.jmb.2010.04.055. Epub 2010 May 4. J Mol Biol. 2010. PMID: 20447407
63 results