Saxena A - Search Results

1

Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity.

Butini S, Guarino E, Campiani G, Brindisi M, Coccone SS, Fiorini I, Novellino E, Belinskaya T, Saxena A, Gemma S. Butini S, et al. Among authors: saxena a. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5213-6. doi: 10.1016/j.bmcl.2008.08.076. Epub 2008 Aug 26. Bioorg Med Chem Lett. 2008. PMID: 18786825

2

Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring.

Campiani G, Kozikowski AP, Wang S, Ming L, Nacci V, Saxena A, Doctor BP. Campiani G, et al. Among authors: saxena a. Bioorg Med Chem Lett. 1998 Jun 2;8(11):1413-8. doi: 10.1016/s0960-894x(98)00229-7. Bioorg Med Chem Lett. 1998. PMID: 9871776 Free article.

3

Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase.

Savini L, Campiani G, Gaeta A, Pellerano C, Fattorusso C, Chiasserini L, Fedorko JM, Saxena A. Savini L, et al. Among authors: saxena a. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1779-82. doi: 10.1016/s0960-894x(01)00294-3. Bioorg Med Chem Lett. 2001. PMID: 11425559

4

Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B.

Rajendran V, Saxena A, Doctor BP, Kozikowski AP. Rajendran V, et al. Among authors: saxena a. Bioorg Med Chem Lett. 2002 Jun 3;12(11):1521-3. doi: 10.1016/s0960-894x(02)00204-4. Bioorg Med Chem Lett. 2002. PMID: 12031333

5

Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.

Savini L, Gaeta A, Fattorusso C, Catalanotti B, Campiani G, Chiasserini L, Pellerano C, Novellino E, McKissic D, Saxena A. Savini L, et al. Among authors: saxena a. J Med Chem. 2003 Jan 2;46(1):1-4. doi: 10.1021/jm0255668. J Med Chem. 2003. PMID: 12502352

6

Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.

Campiani G, Fattorusso C, Butini S, Gaeta A, Agnusdei M, Gemma S, Persico M, Catalanotti B, Savini L, Nacci V, Novellino E, Holloway HW, Greig NH, Belinskaya T, Fedorko JM, Saxena A. Campiani G, et al. Among authors: saxena a. J Med Chem. 2005 Mar 24;48(6):1919-29. doi: 10.1021/jm049510k. J Med Chem. 2005. PMID: 15771436

7

Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.

Gemma S, Gabellieri E, Huleatt P, Fattorusso C, Borriello M, Catalanotti B, Butini S, De Angelis M, Novellino E, Nacci V, Belinskaya T, Saxena A, Campiani G. Gemma S, et al. Among authors: saxena a. J Med Chem. 2006 Jun 1;49(11):3421-5. doi: 10.1021/jm060257t. J Med Chem. 2006. PMID: 16722663

8

Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.

Butini S, Campiani G, Borriello M, Gemma S, Panico A, Persico M, Catalanotti B, Ros S, Brindisi M, Agnusdei M, Fiorini I, Nacci V, Novellino E, Belinskaya T, Saxena A, Fattorusso C. Butini S, et al. Among authors: saxena a. J Med Chem. 2008 Jun 12;51(11):3154-70. doi: 10.1021/jm701253t. Epub 2008 May 15. J Med Chem. 2008. PMID: 18479118

9

In search of a catalytic bioscavenger for the prophylaxis of nerve agent toxicity.

diTargiani RC, Chandrasekaran L, Belinskaya T, Saxena A. diTargiani RC, et al. Among authors: saxena a. Chem Biol Interact. 2010 Sep 6;187(1-3):349-54. doi: 10.1016/j.cbi.2010.02.021. Epub 2010 Feb 20. Chem Biol Interact. 2010. PMID: 20176006

10

Differences in amino acid residues in the binding pockets dictate substrate specificities of mouse senescence marker protein-30, human paraoxonase1, and squid diisopropylfluorophosphatase.

Belinskaya T, Pattabiraman N, diTargiani R, Choi M, Saxena A. Belinskaya T, et al. Among authors: saxena a. Biochim Biophys Acta. 2012 May;1824(5):701-10. doi: 10.1016/j.bbapap.2012.02.007. Epub 2012 Feb 28. Biochim Biophys Acta. 2012. PMID: 22401958

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