Lum RT - Search Results

1

Design, synthesis, and structure-activity relationships of novel insulin receptor tyrosine kinase activators.

Lum RT, Cheng M, Cristobal CP, Goldfine ID, Evans JL, Keck JG, Macsata RW, Manchem VP, Matsumoto Y, Park SJ, Rao SS, Robinson L, Shi S, Spevak WR, Schow SR. Lum RT, et al. J Med Chem. 2008 Oct 9;51(19):6173-87. doi: 10.1021/jm800600v. Epub 2008 Sep 13. J Med Chem. 2008. PMID: 18788731

2

In vitro and in vivo prevention of HIV protease inhibitor-induced insulin resistance by a novel small molecule insulin receptor activator.

Cheng M, Chen S, Schow SR, Manchem VP, Spevak WR, Cristobal CP, Shi S, Macsata RW, Lum RT, Goldfine ID, Keck JG. Cheng M, et al. Among authors: lum rt. J Cell Biochem. 2004 Aug 15;92(6):1234-45. doi: 10.1002/jcb.20150. J Cell Biochem. 2004. PMID: 15258906

3

Novel cyclooxygenase-1 inhibitors discovered using affinity fingerprints.

Hsu N, Cai D, Damodaran K, Gomez RF, Keck JG, Laborde E, Lum RT, Macke TJ, Martin G, Schow SR, Simon RJ, Villar HO, Wick MM, Beroza P. Hsu N, et al. Among authors: lum rt. J Med Chem. 2004 Sep 23;47(20):4875-80. doi: 10.1021/jm049950b. J Med Chem. 2004. PMID: 15369391

4

5-Substituted isophthalamides as insulin receptor sensitizers.

Robinson L, Bajjalieh S, Cairns N, Lum RT, Macsata RW, Manchem VP, Park SJ, Rao S, Schow SR, Shi S, Spevak WR. Robinson L, et al. Among authors: lum rt. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3492-4. doi: 10.1016/j.bmcl.2008.05.031. Epub 2008 May 15. Bioorg Med Chem Lett. 2008. PMID: 18513965

5

A novel small molecule that directly sensitizes the insulin receptor in vitro and in vivo.

Manchem VP, Goldfine ID, Kohanski RA, Cristobal CP, Lum RT, Schow SR, Shi S, Spevak WR, Laborde E, Toavs DK, Villar HO, Wick MM, Kozlowski MR. Manchem VP, et al. Among authors: lum rt. Diabetes. 2001 Apr;50(4):824-30. doi: 10.2337/diabetes.50.4.824. Diabetes. 2001. PMID: 11289048

6

Selective inhibition of the chymotrypsin-like activity of the 20S proteasome by 5-methoxy-1-indanone dipeptide benzamides.

Lum RT, Nelson MG, Joly A, Horsma AG, Lee G, Meyer SM, Wick MM, Schow SR. Lum RT, et al. Bioorg Med Chem Lett. 1998 Feb 3;8(3):209-14. doi: 10.1016/s0960-894x(98)00015-8. Bioorg Med Chem Lett. 1998. PMID: 9871656

7

CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation.

Brooks EE, Gray NS, Joly A, Kerwar SS, Lum R, Mackman RL, Norman TC, Rosete J, Rowe M, Schow SR, Schultz PG, Wang X, Wick MM, Shiffman D. Brooks EE, et al. J Biol Chem. 1997 Nov 14;272(46):29207-11. doi: 10.1074/jbc.272.46.29207. J Biol Chem. 1997. PMID: 9360999 Free article.

8

A new structural class of proteasome inhibitors that prevent NF-kappa B activation.

Lum RT, Kerwar SS, Meyer SM, Nelson MG, Schow SR, Shiffman D, Wick MM, Joly A. Lum RT, et al. Biochem Pharmacol. 1998 May 1;55(9):1391-7. doi: 10.1016/s0006-2952(97)00655-2. Biochem Pharmacol. 1998. PMID: 10076530

9

Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine.

Pfister JR, Belardinelli L, Lee G, Lum RT, Milner P, Stanley WC, Linden J, Baker SP, Schreiner G. Pfister JR, et al. Among authors: lum rt. J Med Chem. 1997 Jun 6;40(12):1773-8. doi: 10.1021/jm970013w. J Med Chem. 1997. PMID: 9191953

10

Phase I study of TLK286 (glutathione S-transferase P1-1 activated glutathione analogue) in advanced refractory solid malignancies.

Rosen LS, Brown J, Laxa B, Boulos L, Reiswig L, Henner WD, Lum RT, Schow SR, Maack CA, Keck JG, Mascavage JC, Dombroski JA, Gomez RF, Brown GL. Rosen LS, et al. Among authors: lum rt. Clin Cancer Res. 2003 May;9(5):1628-38. Clin Cancer Res. 2003. PMID: 12738715 Clinical Trial.

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