Manchem VP - Search Results

1

Design, synthesis, and structure-activity relationships of novel insulin receptor tyrosine kinase activators.

Lum RT, Cheng M, Cristobal CP, Goldfine ID, Evans JL, Keck JG, Macsata RW, Manchem VP, Matsumoto Y, Park SJ, Rao SS, Robinson L, Shi S, Spevak WR, Schow SR. Lum RT, et al. Among authors: manchem vp. J Med Chem. 2008 Oct 9;51(19):6173-87. doi: 10.1021/jm800600v. Epub 2008 Sep 13. J Med Chem. 2008. PMID: 18788731

2

Regulation of insulin receptor function by a small molecule insulin receptor activator.

Pender C, Goldfine ID, Manchem VP, Evans JL, Spevak WR, Shi S, Rao S, Bajjalieh S, Maddux BA, Youngren JF. Pender C, et al. Among authors: manchem vp. J Biol Chem. 2002 Nov 15;277(46):43565-71. doi: 10.1074/jbc.M202426200. Epub 2002 Sep 3. J Biol Chem. 2002. PMID: 12213804 Free article.

3

In vitro and in vivo prevention of HIV protease inhibitor-induced insulin resistance by a novel small molecule insulin receptor activator.

Cheng M, Chen S, Schow SR, Manchem VP, Spevak WR, Cristobal CP, Shi S, Macsata RW, Lum RT, Goldfine ID, Keck JG. Cheng M, et al. Among authors: manchem vp. J Cell Biochem. 2004 Aug 15;92(6):1234-45. doi: 10.1002/jcb.20150. J Cell Biochem. 2004. PMID: 15258906

4

5-Substituted isophthalamides as insulin receptor sensitizers.

Robinson L, Bajjalieh S, Cairns N, Lum RT, Macsata RW, Manchem VP, Park SJ, Rao S, Schow SR, Shi S, Spevak WR. Robinson L, et al. Among authors: manchem vp. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3492-4. doi: 10.1016/j.bmcl.2008.05.031. Epub 2008 May 15. Bioorg Med Chem Lett. 2008. PMID: 18513965

5

A novel small molecule that directly sensitizes the insulin receptor in vitro and in vivo.

Manchem VP, Goldfine ID, Kohanski RA, Cristobal CP, Lum RT, Schow SR, Shi S, Spevak WR, Laborde E, Toavs DK, Villar HO, Wick MM, Kozlowski MR. Manchem VP, et al. Diabetes. 2001 Apr;50(4):824-30. doi: 10.2337/diabetes.50.4.824. Diabetes. 2001. PMID: 11289048

6

Small molecule insulin receptor activators potentiate insulin action in insulin-resistant cells.

Li M, Youngren JF, Manchem VP, Kozlowski M, Zhang BB, Maddux BA, Goldfine ID. Li M, et al. Among authors: manchem vp. Diabetes. 2001 Oct;50(10):2323-8. doi: 10.2337/diabetes.50.10.2323. Diabetes. 2001. PMID: 11574415

7

Small molecule activators of the insulin receptor: potential new therapeutic agents for the treatment of diabetes mellitus.

Laborde E, Manchem VP. Laborde E, et al. Among authors: manchem vp. Curr Med Chem. 2002 Dec;9(24):2231-42. doi: 10.2174/0929867023368665. Curr Med Chem. 2002. PMID: 12470244 Review.

8

Reduction of low molecular weight protein-tyrosine phosphatase expression improves hyperglycemia and insulin sensitivity in obese mice.

Pandey SK, Yu XX, Watts LM, Michael MD, Sloop KW, Rivard AR, Leedom TA, Manchem VP, Samadzadeh L, McKay RA, Monia BP, Bhanot S. Pandey SK, et al. Among authors: manchem vp. J Biol Chem. 2007 May 11;282(19):14291-9. doi: 10.1074/jbc.M609626200. Epub 2007 Mar 12. J Biol Chem. 2007. PMID: 17353188 Free article.

9

Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism.

Watts LM, Manchem VP, Leedom TA, Rivard AL, McKay RA, Bao D, Neroladakis T, Monia BP, Bodenmiller DM, Cao JX, Zhang HY, Cox AL, Jacobs SJ, Michael MD, Sloop KW, Bhanot S. Watts LM, et al. Among authors: manchem vp. Diabetes. 2005 Jun;54(6):1846-53. doi: 10.2337/diabetes.54.6.1846. Diabetes. 2005. PMID: 15919808

10

Peripheral reduction of FGFR4 with antisense oligonucleotides increases metabolic rate and lowers adiposity in diet-induced obese mice.

Yu XX, Watts LM, Manchem VP, Chakravarty K, Monia BP, McCaleb ML, Bhanot S. Yu XX, et al. Among authors: manchem vp. PLoS One. 2013 Jul 29;8(7):e66923. doi: 10.1371/journal.pone.0066923. Print 2013. PLoS One. 2013. PMID: 23922646 Free PMC article.

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