Schow SR - Search Results

1

Design, synthesis, and structure-activity relationships of novel insulin receptor tyrosine kinase activators.

Lum RT, Cheng M, Cristobal CP, Goldfine ID, Evans JL, Keck JG, Macsata RW, Manchem VP, Matsumoto Y, Park SJ, Rao SS, Robinson L, Shi S, Spevak WR, Schow SR. Lum RT, et al. Among authors: schow sr. J Med Chem. 2008 Oct 9;51(19):6173-87. doi: 10.1021/jm800600v. Epub 2008 Sep 13. J Med Chem. 2008. PMID: 18788731

2

Discovery, optimization, and pharmacological characterization of novel heteroaroylphenylureas antagonists of C-C chemokine ligand 2 function.

Laborde E, Macsata RW, Meng F, Peterson BT, Robinson L, Schow SR, Simon RJ, Xu H, Baba K, Inagaki H, Ishiwata Y, Jomori T, Matsumoto Y, Miyachi A, Nakamura T, Okamoto M, Handel TM, Bernard CC. Laborde E, et al. Among authors: schow sr. J Med Chem. 2011 Mar 24;54(6):1667-81. doi: 10.1021/jm1012903. Epub 2011 Feb 22. J Med Chem. 2011. PMID: 21341682 Free PMC article.

3

In vitro and in vivo prevention of HIV protease inhibitor-induced insulin resistance by a novel small molecule insulin receptor activator.

Cheng M, Chen S, Schow SR, Manchem VP, Spevak WR, Cristobal CP, Shi S, Macsata RW, Lum RT, Goldfine ID, Keck JG. Cheng M, et al. Among authors: schow sr. J Cell Biochem. 2004 Aug 15;92(6):1234-45. doi: 10.1002/jcb.20150. J Cell Biochem. 2004. PMID: 15258906

4

Novel cyclooxygenase-1 inhibitors discovered using affinity fingerprints.

Hsu N, Cai D, Damodaran K, Gomez RF, Keck JG, Laborde E, Lum RT, Macke TJ, Martin G, Schow SR, Simon RJ, Villar HO, Wick MM, Beroza P. Hsu N, et al. Among authors: schow sr. J Med Chem. 2004 Sep 23;47(20):4875-80. doi: 10.1021/jm049950b. J Med Chem. 2004. PMID: 15369391

5

5-Substituted isophthalamides as insulin receptor sensitizers.

Robinson L, Bajjalieh S, Cairns N, Lum RT, Macsata RW, Manchem VP, Park SJ, Rao S, Schow SR, Shi S, Spevak WR. Robinson L, et al. Among authors: schow sr. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3492-4. doi: 10.1016/j.bmcl.2008.05.031. Epub 2008 May 15. Bioorg Med Chem Lett. 2008. PMID: 18513965

6

A novel small molecule that directly sensitizes the insulin receptor in vitro and in vivo.

Manchem VP, Goldfine ID, Kohanski RA, Cristobal CP, Lum RT, Schow SR, Shi S, Spevak WR, Laborde E, Toavs DK, Villar HO, Wick MM, Kozlowski MR. Manchem VP, et al. Among authors: schow sr. Diabetes. 2001 Apr;50(4):824-30. doi: 10.2337/diabetes.50.4.824. Diabetes. 2001. PMID: 11289048

7

Selective inhibition of the chymotrypsin-like activity of the 20S proteasome by 5-methoxy-1-indanone dipeptide benzamides.

Lum RT, Nelson MG, Joly A, Horsma AG, Lee G, Meyer SM, Wick MM, Schow SR. Lum RT, et al. Among authors: schow sr. Bioorg Med Chem Lett. 1998 Feb 3;8(3):209-14. doi: 10.1016/s0960-894x(98)00015-8. Bioorg Med Chem Lett. 1998. PMID: 9871656

8

Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth.

Gable KL, Maddux BA, Penaranda C, Zavodovskaya M, Campbell MJ, Lobo M, Robinson L, Schow S, Kerner JA, Goldfine ID, Youngren JF. Gable KL, et al. Mol Cancer Ther. 2006 Apr;5(4):1079-86. doi: 10.1158/1535-7163.MCT-05-0397. Mol Cancer Ther. 2006. PMID: 16648580

9

A new structural class of proteasome inhibitors that prevent NF-kappa B activation.

Lum RT, Kerwar SS, Meyer SM, Nelson MG, Schow SR, Shiffman D, Wick MM, Joly A. Lum RT, et al. Among authors: schow sr. Biochem Pharmacol. 1998 May 1;55(9):1391-7. doi: 10.1016/s0006-2952(97)00655-2. Biochem Pharmacol. 1998. PMID: 10076530

10

Phase I study of TLK286 (glutathione S-transferase P1-1 activated glutathione analogue) in advanced refractory solid malignancies.

Rosen LS, Brown J, Laxa B, Boulos L, Reiswig L, Henner WD, Lum RT, Schow SR, Maack CA, Keck JG, Mascavage JC, Dombroski JA, Gomez RF, Brown GL. Rosen LS, et al. Among authors: schow sr. Clin Cancer Res. 2003 May;9(5):1628-38. Clin Cancer Res. 2003. PMID: 12738715 Clinical Trial.

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