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Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8alpha+ dendritic cells.
Lundie RJ, de Koning-Ward TF, Davey GM, Nie CQ, Hansen DS, Lau LS, Mintern JD, Belz GT, Schofield L, Carbone FR, Villadangos JA, Crabb BS, Heath WR. Lundie RJ, et al. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14509-14. doi: 10.1073/pnas.0806727105. Epub 2008 Sep 17. Proc Natl Acad Sci U S A. 2008. PMID: 18799734 Free PMC article.
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity.
Edgar RCS, Malcolm TR, Siddiqui G, Giannangelo C, Counihan NA, Challis M, Duffy S, Chowdhury M, Marfurt J, Dans M, Wirjanata G, Noviyanti R, Daware K, Suraweera CD, Price RN, Wittlin S, Avery VM, Drinkwater N, Charman SA, Creek DJ, de Koning-Ward TF, Scammells PJ, McGowan S. Edgar RCS, et al. Among authors: de koning ward tf. mBio. 2024 Jun 12;15(6):e0096624. doi: 10.1128/mbio.00966-24. Epub 2024 May 8. mBio. 2024. PMID: 38717141 Free PMC article.
Evidence that invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein-1 (MSP-1 19) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of Africa.
John CC, O'Donnell RA, Sumba PO, Moormann AM, de Koning-Ward TF, King CL, Kazura JW, Crabb BS. John CC, et al. J Immunol. 2004 Jul 1;173(1):666-72. doi: 10.4049/jimmunol.173.1.666. J Immunol. 2004. PMID: 15210830
101 results