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Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.
Park JH, Adoro S, Guinter T, Erman B, Alag AS, Catalfamo M, Kimura MY, Cui Y, Lucas PJ, Gress RE, Kubo M, Hennighausen L, Feigenbaum L, Singer A. Park JH, et al. Among authors: cui y. Nat Immunol. 2010 Mar;11(3):257-64. doi: 10.1038/ni.1840. Epub 2010 Jan 31. Nat Immunol. 2010. PMID: 20118929 Free PMC article.
Stat5a/b are essential for normal lymphoid development and differentiation.
Yao Z, Cui Y, Watford WT, Bream JH, Yamaoka K, Hissong BD, Li D, Durum SK, Jiang Q, Bhandoola A, Hennighausen L, O'Shea JJ. Yao Z, et al. Among authors: cui y. Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1000-5. doi: 10.1073/pnas.0507350103. Epub 2006 Jan 17. Proc Natl Acad Sci U S A. 2006. PMID: 16418296 Free PMC article.
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