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Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.
Mitra S, Ring AM, Amarnath S, Spangler JB, Li P, Ju W, Fischer S, Oh J, Spolski R, Weiskopf K, Kohrt H, Foley JE, Rajagopalan S, Long EO, Fowler DH, Waldmann TA, Garcia KC, Leonard WJ. Mitra S, et al. Among authors: oh j. Immunity. 2015 May 19;42(5):826-38. doi: 10.1016/j.immuni.2015.04.018. Immunity. 2015. PMID: 25992859 Free PMC article.
Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+ T cells.
Wan CK, Andraski AB, Spolski R, Li P, Kazemian M, Oh J, Samsel L, Swanson PA 2nd, McGavern DB, Sampaio EP, Freeman AF, Milner JD, Holland SM, Leonard WJ. Wan CK, et al. Among authors: oh j. Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9394-9. doi: 10.1073/pnas.1511711112. Epub 2015 Jul 13. Proc Natl Acad Sci U S A. 2015. PMID: 26170288 Free PMC article.
Genetic background-dependent role of Egr1 for eyelid development.
Oh J, Wang Y, Chen S, Li P, Du N, Yu ZX, Butcher D, Gebregiorgis T, Strachan E, Lehmann OJ, Brooks BP, Chan CC, Leonard WJ. Oh J, et al. Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7131-E7139. doi: 10.1073/pnas.1705848114. Epub 2017 Aug 4. Proc Natl Acad Sci U S A. 2017. PMID: 28778995 Free PMC article.
STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of the Il2ra gene locus.
Li P, Mitra S, Spolski R, Oh J, Liao W, Tang Z, Mo F, Li X, West EE, Gromer D, Lin JX, Liu C, Ruan Y, Leonard WJ. Li P, et al. Among authors: oh j. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12111-12119. doi: 10.1073/pnas.1714019114. Epub 2017 Oct 24. Proc Natl Acad Sci U S A. 2017. PMID: 29078395 Free PMC article.
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