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The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice.
Thomas EA, Coppola G, Desplats PA, Tang B, Soragni E, Burnett R, Gao F, Fitzgerald KM, Borok JF, Herman D, Geschwind DH, Gottesfeld JM. Thomas EA, et al. Among authors: gottesfeld jm. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15564-9. doi: 10.1073/pnas.0804249105. Epub 2008 Sep 30. Proc Natl Acad Sci U S A. 2008. PMID: 18829438 Free PMC article.
Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease.
Jia H, Pallos J, Jacques V, Lau A, Tang B, Cooper A, Syed A, Purcell J, Chen Y, Sharma S, Sangrey GR, Darnell SB, Plasterer H, Sadri-Vakili G, Gottesfeld JM, Thompson LM, Rusche JR, Marsh JL, Thomas EA. Jia H, et al. Among authors: gottesfeld jm. Neurobiol Dis. 2012 May;46(2):351-61. doi: 10.1016/j.nbd.2012.01.016. Neurobiol Dis. 2012. PMID: 22590724 Free PMC article.
Translating HDAC inhibitors in Friedreich's ataxia.
Soragni E, Gottesfeld JM. Soragni E, et al. Among authors: gottesfeld jm. Expert Opin Orphan Drugs. 2016;4(9):961-970. doi: 10.1080/21678707.2016.1215910. Epub 2016 Jul 31. Expert Opin Orphan Drugs. 2016. PMID: 28392990 Free PMC article.
139 results