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DcpS as a therapeutic target for spinal muscular atrophy.
Singh J, Salcius M, Liu SW, Staker BL, Mishra R, Thurmond J, Michaud G, Mattoon DR, Printen J, Christensen J, Bjornsson JM, Pollok BA, Kiledjian M, Stewart L, Jarecki J, Gurney ME. Singh J, et al. Among authors: stewart l. ACS Chem Biol. 2008 Nov 21;3(11):711-22. doi: 10.1021/cb800120t. ACS Chem Biol. 2008. PMID: 18839960 Free PMC article.
The mechanism of topoisomerase I poisoning by a camptothecin analog.
Staker BL, Hjerrild K, Feese MD, Behnke CA, Burgin AB Jr, Stewart L. Staker BL, et al. Among authors: stewart l. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15387-92. doi: 10.1073/pnas.242259599. Epub 2002 Nov 8. Proc Natl Acad Sci U S A. 2002. PMID: 12426403 Free PMC article.
Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex.
Staker BL, Feese MD, Cushman M, Pommier Y, Zembower D, Stewart L, Burgin AB. Staker BL, et al. Among authors: stewart l. J Med Chem. 2005 Apr 7;48(7):2336-45. doi: 10.1021/jm049146p. J Med Chem. 2005. PMID: 15801827
Annu. Rev. Biochem. 2001, 70, 369-413. Stewart, L.; et al. Science 1998, 729, 1534-1541.) We report the X-ray crystal structures of the human top1-DNA complex bound with camptothecin and representative members of the indenoisoquinoline and indolocarbazole classes of …
Annu. Rev. Biochem. 2001, 70, 369-413. Stewart, L.; et al. Science 1998, 729, 1534-1541.) We report the X-ray crystal structur …
Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis.
Sandanayaka V, Mamat B, Mishra RK, Winger J, Krohn M, Zhou LM, Keyvan M, Enache L, Sullins D, Onua E, Zhang J, Halldorsdottir G, Sigthorsdottir H, Thorlaksdottir A, Sigthorsson G, Thorsteinnsdottir M, Davies DR, Stewart LJ, Zembower DE, Andresson T, Kiselyov AS, Singh J, Gurney ME. Sandanayaka V, et al. Among authors: stewart lj. J Med Chem. 2010 Jan 28;53(2):573-85. doi: 10.1021/jm900838g. J Med Chem. 2010. PMID: 19950900
Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei.
Begley DW, Hartley RC, Davies DR, Edwards TE, Leonard JT, Abendroth J, Burris CA, Bhandari J, Myler PJ, Staker BL, Stewart LJ. Begley DW, et al. Among authors: stewart lj. J Struct Funct Genomics. 2011 Jul;12(2):63-76. doi: 10.1007/s10969-011-9102-6. Epub 2011 Feb 26. J Struct Funct Genomics. 2011. PMID: 21359640 Free PMC article.
1,671 results