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The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines.
Gibbs JE, Blaikley J, Beesley S, Matthews L, Simpson KD, Boyce SH, Farrow SN, Else KJ, Singh D, Ray DW, Loudon AS. Gibbs JE, et al. Among authors: beesley s. Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):582-7. doi: 10.1073/pnas.1106750109. Epub 2011 Dec 19. Proc Natl Acad Sci U S A. 2012. PMID: 22184247 Free PMC article.
Circadian variation in pulmonary inflammatory responses is independent of rhythmic glucocorticoid signaling in airway epithelial cells.
Ince LM, Zhang Z, Beesley S, Vonslow RM, Saer BR, Matthews LC, Begley N, Gibbs JE, Ray DW, Loudon ASI. Ince LM, et al. Among authors: beesley s. FASEB J. 2019 Jan;33(1):126-139. doi: 10.1096/fj.201800026RR. Epub 2018 Jul 2. FASEB J. 2019. PMID: 29965797 Free PMC article.
These new data show GR is required to confer circadian control to some inflammatory chemokines, but that this alone is insufficient to prevent circadian control of neutrophilic inflammation in response to inhaled LPS, with additional control mechanisms arising in the myeloid cell …
These new data show GR is required to confer circadian control to some inflammatory chemokines, but that this alone is insufficient to preve …
A tunable artificial circadian clock in clock-defective mice.
D'Alessandro M, Beesley S, Kim JK, Chen R, Abich E, Cheng W, Yi P, Takahashi JS, Lee C. D'Alessandro M, et al. Among authors: beesley s. Nat Commun. 2015 Nov 30;6:8587. doi: 10.1038/ncomms9587. Nat Commun. 2015. PMID: 26617050 Free PMC article.
115 results