Schäfer S - Search Results

1

Failure is an option: learning from unsuccessful proof-of-concept trials.

Schäfer S, Kolkhof P. Schäfer S, et al. Drug Discov Today. 2008 Nov;13(21-22):913-6. doi: 10.1016/j.drudis.2008.03.026. Epub 2008 Jun 17. Drug Discov Today. 2008. PMID: 18954804 Review.

2

Cardiac glycosides potently inhibit C-reactive protein synthesis in human hepatocytes.

Kolkhof P, Geerts A, Schäfer S, Torzewski J. Kolkhof P, et al. Among authors: schafer s. Biochem Biophys Res Commun. 2010 Mar 26;394(1):233-9. doi: 10.1016/j.bbrc.2010.02.177. Epub 2010 Mar 3. Biochem Biophys Res Commun. 2010. PMID: 20206126

3

A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule.

Fagart J, Hillisch A, Huyet J, Bärfacker L, Fay M, Pleiss U, Pook E, Schäfer S, Rafestin-Oblin ME, Kolkhof P. Fagart J, et al. Among authors: schafer s. J Biol Chem. 2010 Sep 24;285(39):29932-40. doi: 10.1074/jbc.M110.131342. Epub 2010 Jul 22. J Biol Chem. 2010. PMID: 20650892 Free PMC article.

4

Finerenone, a novel selective nonsteroidal mineralocorticoid receptor antagonist protects from rat cardiorenal injury.

Kolkhof P, Delbeck M, Kretschmer A, Steinke W, Hartmann E, Bärfacker L, Eitner F, Albrecht-Küpper B, Schäfer S. Kolkhof P, et al. Among authors: schafer s. J Cardiovasc Pharmacol. 2014 Jul;64(1):69-78. doi: 10.1097/FJC.0000000000000091. J Cardiovasc Pharmacol. 2014. PMID: 24621652

5

Mineralocorticoid receptor-mediated DNA damage in kidneys of DOCA-salt hypertensive rats.

Schupp N, Kolkhof P, Queisser N, Gärtner S, Schmid U, Kretschmer A, Hartmann E, Oli RG, Schäfer S, Stopper H. Schupp N, et al. Among authors: schafer s. FASEB J. 2011 Mar;25(3):968-78. doi: 10.1096/fj.10-173286. Epub 2010 Dec 6. FASEB J. 2011. PMID: 21135038

6

Aldosterone causes DNA strand breaks and chromosomal damage in renal cells, which are prevented by mineralocorticoid receptor antagonists.

Schupp N, Queisser N, Wolf M, Kolkhof P, Bärfacker L, Schäfer S, Heidland A, Stopper H. Schupp N, et al. Among authors: schafer s. Horm Metab Res. 2010 Jun;42(6):458-65. doi: 10.1055/s-0029-1243253. Epub 2010 Jan 21. Horm Metab Res. 2010. PMID: 20094972

7

One target-multiple indications: a call for an integrated common mechanisms strategy.

Nielsch U, Schäfer S, Wild H, Busch A. Nielsch U, et al. Among authors: schafer s. Drug Discov Today. 2007 Dec;12(23-24):1025-31. doi: 10.1016/j.drudis.2007.10.004. Epub 2007 Nov 26. Drug Discov Today. 2007. PMID: 18061881 Review.

8

A role for coagulation factor Xa in experimental pulmonary arterial hypertension.

Delbeck M, Nickel KF, Perzborn E, Ellinghaus P, Strassburger J, Kast R, Laux V, Schäfer S, Schermuly RT, von Degenfeld G. Delbeck M, et al. Among authors: schafer s. Cardiovasc Res. 2011 Oct 1;92(1):159-68. doi: 10.1093/cvr/cvr168. Epub 2011 Jun 15. Cardiovasc Res. 2011. PMID: 21676958

9

Impaired left-ventricular cardiac function in male GPR30-deficient mice.

Delbeck M, Golz S, Vonk R, Janssen W, Hucho T, Isensee J, Schäfer S, Otto C. Delbeck M, et al. Among authors: schafer s. Mol Med Rep. 2011 Jan-Feb;4(1):37-40. doi: 10.3892/mmr.2010.402. Epub 2010 Nov 30. Mol Med Rep. 2011. PMID: 21461560

10

[Management of high blood pressure and cardiac insufficiency. New drugs and therapeutic concepts].

Schäfer S, Busch AE. Schäfer S, et al. Pharm Unserer Zeit. 2003;32(1):54-9. doi: 10.1002/pauz.200390009. Pharm Unserer Zeit. 2003. PMID: 12577761 Review. German. No abstract available.

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