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Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice.
Klein C, Nguyen D, Liu CH, Mizoguchi A, Bhan AK, Miki H, Takenawa T, Rosen FS, Alt FW, Mulligan RC, Snapper SB. Klein C, et al. Among authors: snapper sb. Blood. 2003 Mar 15;101(6):2159-66. doi: 10.1182/blood-2002-05-1423. Epub 2002 Nov 14. Blood. 2003. PMID: 12433691 Free article.
Retroviral WASP gene transfer into human hematopoietic stem cells reconstitutes the actin cytoskeleton in myeloid progeny cells differentiated in vitro.
Dewey RA, Avedillo Díez I, Ballmaier M, Filipovich A, Greil J, Güngör T, Happel C, Maschan A, Noyan F, Pannicke U, Schwarz K, Snapper S, Welte K, Klein C. Dewey RA, et al. Exp Hematol. 2006 Sep;34(9):1161-9. doi: 10.1016/j.exphem.2006.04.021. Exp Hematol. 2006. PMID: 16939809 Free article. Clinical Trial.
Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.
Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung UI, Xavier R, Alt FW, Snapper SB. Cotta-de-Almeida V, et al. Among authors: snapper sb. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15424-9. doi: 10.1073/pnas.0706881104. Epub 2007 Sep 18. Proc Natl Acad Sci U S A. 2007. PMID: 17878299 Free PMC article.
248 results