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Transcription destabilizes triplet repeats.
Lin Y, Hubert L Jr, Wilson JH. Lin Y, et al. Mol Carcinog. 2009 Apr;48(4):350-61. doi: 10.1002/mc.20488. Mol Carcinog. 2009. PMID: 18973172 Free PMC article. Review.
Transcription-induced CAG repeat contraction in human cells is mediated in part by transcription-coupled nucleotide excision repair.
Lin Y, Wilson JH. Lin Y, et al. Mol Cell Biol. 2007 Sep;27(17):6209-17. doi: 10.1128/MCB.00739-07. Epub 2007 Jun 25. Mol Cell Biol. 2007. PMID: 17591697 Free PMC article.
We showed previously that transcription through CAG repeats induces their instability (Y. Lin, V. Dion, and J. H. Wilson, Nat. Struct. Mol. Biol. 13:179-180). Here, we present a genetic analysis of the link between transcription-induced repeat instability and nucleo …
We showed previously that transcription through CAG repeats induces their instability (Y. Lin, V. Dion, and J. H. Wilson, Nat. …
Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells.
Lin Y, Wilson JH. Lin Y, et al. DNA Repair (Amst). 2009 Aug 6;8(8):878-85. doi: 10.1016/j.dnarep.2009.04.024. Epub 2009 Jun 3. DNA Repair (Amst). 2009. PMID: 19497791 Free PMC article.
We showed previously that transcription through a CAG repeat tract induces repeat instability in human cells via a pathway that requires the mismatch repair (MMR) components, MSH2 and MSH3, and the entire transcription-coupled nucleotide excision repair pathway [Y. Lin …
We showed previously that transcription through a CAG repeat tract induces repeat instability in human cells via a pathway that requires the …
R loops stimulate genetic instability of CTG.CAG repeats.
Lin Y, Dent SY, Wilson JH, Wells RD, Napierala M. Lin Y, et al. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):692-7. doi: 10.1073/pnas.0909740107. Epub 2009 Dec 22. Proc Natl Acad Sci U S A. 2010. PMID: 20080737 Free PMC article.
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