Yi H - Search Results

1

SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.

Lu J, Bai L, Sun H, Nikolovska-Coleska Z, McEachern D, Qiu S, Miller RS, Yi H, Shangary S, Sun Y, Meagher JL, Stuckey JA, Wang S. Lu J, et al. Among authors: yi h. Cancer Res. 2008 Nov 15;68(22):9384-93. doi: 10.1158/0008-5472.CAN-08-2655. Cancer Res. 2008. PMID: 19010913 Free PMC article.

2

Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains.

Nikolovska-Coleska Z, Meagher JL, Jiang S, Kawamoto SA, Gao W, Yi H, Qin D, Roller PP, Stuckey JA, Wang S. Nikolovska-Coleska Z, et al. Among authors: yi h. Anal Biochem. 2008 Mar 1;374(1):87-98. doi: 10.1016/j.ab.2007.10.032. Epub 2007 Nov 20. Anal Biochem. 2008. PMID: 18023397

3

Potent, orally bioavailable diazabicyclic small-molecule mimetics of second mitochondria-derived activator of caspases.

Peng Y, Sun H, Nikolovska-Coleska Z, Qiu S, Yang CY, Lu J, Cai Q, Yi H, Kang S, Yang D, Wang S. Peng Y, et al. Among authors: yi h. J Med Chem. 2008 Dec 25;51(24):8158-62. doi: 10.1021/jm801254r. J Med Chem. 2008. PMID: 19049347 Free PMC article.

4

Cyclopeptide Smac mimetics as antagonists of IAP proteins.

Sun H, Liu L, Lu J, Qiu S, Yang CY, Yi H, Wang S. Sun H, et al. Among authors: yi h. Bioorg Med Chem Lett. 2010 May 15;20(10):3043-6. doi: 10.1016/j.bmcl.2010.03.114. Bioorg Med Chem Lett. 2010. PMID: 20443226 Free PMC article.

5

Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.

Sun H, Lu J, Liu L, Yi H, Qiu S, Yang CY, Deschamps JR, Wang S. Sun H, et al. Among authors: yi h. J Med Chem. 2010 Sep 9;53(17):6361-7. doi: 10.1021/jm100487z. J Med Chem. 2010. PMID: 20684551 Free PMC article.

6

Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatment.

Lu J, McEachern D, Sun H, Bai L, Peng Y, Qiu S, Miller R, Liao J, Yi H, Liu M, Bellail A, Hao C, Sun SY, Ting AT, Wang S. Lu J, et al. Among authors: yi h. Mol Cancer Ther. 2011 May;10(5):902-14. doi: 10.1158/1535-7163.MCT-10-0864. Epub 2011 Mar 3. Mol Cancer Ther. 2011. PMID: 21372226 Free PMC article.

7

A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.

Cai Q, Sun H, Peng Y, Lu J, Nikolovska-Coleska Z, McEachern D, Liu L, Qiu S, Yang CY, Miller R, Yi H, Zhang T, Sun D, Kang S, Guo M, Leopold L, Yang D, Wang S. Cai Q, et al. Among authors: yi h. J Med Chem. 2011 Apr 28;54(8):2714-26. doi: 10.1021/jm101505d. Epub 2011 Mar 28. J Med Chem. 2011. PMID: 21443232 Free PMC article.

8

Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.

Sun H, Liu L, Lu J, Bai L, Li X, Nikolovska-Coleska Z, McEachern D, Yang CY, Qiu S, Yi H, Sun D, Wang S. Sun H, et al. Among authors: yi h. J Med Chem. 2011 May 12;54(9):3306-18. doi: 10.1021/jm101651b. Epub 2011 Apr 13. J Med Chem. 2011. PMID: 21462933 Free PMC article.

9

Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents.

Peng Y, Sun H, Lu J, Liu L, Cai Q, Shen R, Yang CY, Yi H, Wang S. Peng Y, et al. Among authors: yi h. J Med Chem. 2012 Jan 12;55(1):106-14. doi: 10.1021/jm201072x. Epub 2011 Dec 7. J Med Chem. 2012. PMID: 22148838

10

Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors.

Gomez C, Bai L, Zhang J, Nikolovska-Coleska Z, Chen J, Yi H, Wang S. Gomez C, et al. Among authors: yi h. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1733-6. doi: 10.1016/j.bmcl.2009.01.091. Epub 2009 Jan 31. Bioorg Med Chem Lett. 2009. PMID: 19243938

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