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Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.
Miller LM, Mayer SC, Berger DM, Boschelli DH, Boschelli F, Di L, Du X, Dutia M, Floyd MB, Johnson M, Kenny CH, Krishnamurthy G, Moy F, Petusky S, Tkach D, Torres N, Wu B, Xu W. Miller LM, et al. Among authors: tkach d. Bioorg Med Chem Lett. 2009 Jan 1;19(1):62-6. doi: 10.1016/j.bmcl.2008.11.037. Epub 2008 Nov 17. Bioorg Med Chem Lett. 2009. PMID: 19041240
Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.
Mayer SC, Banker AL, Boschelli F, Di L, Johnson M, Kenny CH, Krishnamurthy G, Kutterer K, Moy F, Petusky S, Ravi M, Tkach D, Tsou HR, Xu W. Mayer SC, et al. Among authors: tkach d. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3641-5. doi: 10.1016/j.bmcl.2008.04.044. Epub 2008 Apr 25. Bioorg Med Chem Lett. 2008. PMID: 18501599
A cell-based screen for inhibitors of protein folding and degradation.
Boschelli F, Golas JM, Petersen R, Lau V, Chen L, Tkach D, Zhao Q, Fruhling DS, Liu H, Nam C, Arndt KT. Boschelli F, et al. Among authors: tkach d. Cell Stress Chaperones. 2010 Nov;15(6):913-27. doi: 10.1007/s12192-010-0200-3. Epub 2010 Aug 19. Cell Stress Chaperones. 2010. PMID: 20717760 Free PMC article.
Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy.
Eng CH, Wang Z, Tkach D, Toral-Barza L, Ugwonali S, Liu S, Fitzgerald SL, George E, Frias E, Cochran N, De Jesus R, McAllister G, Hoffman GR, Bray K, Lemon L, Lucas J, Fantin VR, Abraham RT, Murphy LO, Nyfeler B. Eng CH, et al. Among authors: tkach d. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):182-7. doi: 10.1073/pnas.1515617113. Epub 2015 Dec 17. Proc Natl Acad Sci U S A. 2016. PMID: 26677873 Free PMC article.
AMPK promotes the survival of colorectal cancer stem cells.
Guo B, Han X, Tkach D, Huang SG, Zhang D. Guo B, et al. Among authors: tkach d. Animal Model Exp Med. 2018 Jul 28;1(2):134-142. doi: 10.1002/ame2.12016. eCollection 2018 Jun. Animal Model Exp Med. 2018. PMID: 30891558 Free PMC article.
Efficient multitool/multiplex gene engineering with TALE-BE.
Boyne A, Yang M, Pulicani S, Feola M, Tkach D, Hong R, Duclert A, Duchateau P, Juillerat A. Boyne A, et al. Among authors: tkach d. Front Bioeng Biotechnol. 2022 Nov 10;10:1033669. doi: 10.3389/fbioe.2022.1033669. eCollection 2022. Front Bioeng Biotechnol. 2022. PMID: 36440442 Free PMC article.
Straightforward Generation of Ultrapure Off-the-Shelf Allogeneic CAR-T Cells.
Juillerat A, Tkach D, Yang M, Boyne A, Valton J, Poirot L, Duchateau P. Juillerat A, et al. Among authors: tkach d. Front Bioeng Biotechnol. 2020 Jun 25;8:678. doi: 10.3389/fbioe.2020.00678. eCollection 2020. Front Bioeng Biotechnol. 2020. PMID: 32671047 Free PMC article.
31 results