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259 results

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Page 1
Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity.
Marlo JE, Niswender CM, Days EL, Bridges TM, Xiang Y, Rodriguez AL, Shirey JK, Brady AE, Nalywajko T, Luo Q, Austin CA, Williams MB, Kim K, Williams R, Orton D, Brown HA, Lindsley CW, Weaver CD, Conn PJ. Marlo JE, et al. Among authors: brown ha. Mol Pharmacol. 2009 Mar;75(3):577-88. doi: 10.1124/mol.108.052886. Epub 2008 Dec 1. Mol Pharmacol. 2009. PMID: 19047481 Free PMC article.
Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor.
Lavieri RR, Scott SA, Selvy PE, Kim K, Jadhav S, Morrison RD, Daniels JS, Brown HA, Lindsley CW. Lavieri RR, et al. Among authors: brown ha. J Med Chem. 2010 Sep 23;53(18):6706-19. doi: 10.1021/jm100814g. J Med Chem. 2010. PMID: 20735042 Free PMC article.
Phospholipase D as a therapeutic target in brain disorders.
Lindsley CW, Brown HA. Lindsley CW, et al. Among authors: brown ha. Neuropsychopharmacology. 2012 Jan;37(1):301-2. doi: 10.1038/npp.2011.178. Neuropsychopharmacology. 2012. PMID: 22157867 Free PMC article. No abstract available.
Competition and allostery govern substrate selectivity of cyclooxygenase-2.
Mitchener MM, Hermanson DJ, Shockley EM, Brown HA, Lindsley CW, Reese J, Rouzer CA, Lopez CF, Marnett LJ. Mitchener MM, et al. Among authors: brown ha. Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12366-71. doi: 10.1073/pnas.1507307112. Epub 2015 Sep 21. Proc Natl Acad Sci U S A. 2015. PMID: 26392530 Free PMC article.
Phospholipase D: enzymology, functionality, and chemical modulation.
Selvy PE, Lavieri RR, Lindsley CW, Brown HA. Selvy PE, et al. Among authors: brown ha. Chem Rev. 2011 Oct 12;111(10):6064-119. doi: 10.1021/cr200296t. Epub 2011 Sep 22. Chem Rev. 2011. PMID: 21936578 Free PMC article. Review. No abstract available.
259 results