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31 results

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Page 1
Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines.
Gillespie RJ, Bamford SJ, Botting R, Comer M, Denny S, Gaur S, Griffin M, Jordan AM, Knight AR, Lerpiniere J, Leonardi S, Lightowler S, McAteer S, Merrett A, Misra A, Padfield A, Reece M, Saadi M, Selwood DL, Stratton GC, Surry D, Todd R, Tong X, Ruston V, Upton R, Weiss SM. Gillespie RJ, et al. Among authors: lightowler s. J Med Chem. 2009 Jan 8;52(1):33-47. doi: 10.1021/jm800961g. J Med Chem. 2009. PMID: 19072055
Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor.
Bedford ST, Benwell KR, Brooks T, Chen I, Comer M, Dugdale S, Haymes T, Jordan AM, Kennett GA, Knight AR, Klenke B, LeStrat L, Merrett A, Misra A, Lightowler S, Padfield A, Poullennec K, Reece M, Simmonite H, Wong M, Yule IA. Bedford ST, et al. Among authors: lightowler s. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5945-9. doi: 10.1016/j.bmcl.2009.08.040. Epub 2009 Aug 14. Bioorg Med Chem Lett. 2009. PMID: 19733067
Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity.
Roughley SD, Browne H, Macias AT, Benwell K, Brooks T, D'Alessandro J, Daniels Z, Dugdale S, Francis G, Gibbons B, Hart T, Haymes T, Kennett G, Lightowler S, Matassova N, Mansell H, Merrett A, Misra A, Padfield A, Parsons R, Pratt R, Robertson A, Simmonite H, Tan K, Walls SB, Wong M. Roughley SD, et al. Among authors: lightowler s. Bioorg Med Chem Lett. 2012 Jan 15;22(2):901-6. doi: 10.1016/j.bmcl.2011.12.032. Epub 2011 Dec 13. Bioorg Med Chem Lett. 2012. PMID: 22209458
Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.
Hart T, Macias AT, Benwell K, Brooks T, D'Alessandro J, Dokurno P, Francis G, Gibbons B, Haymes T, Kennett G, Lightowler S, Mansell H, Matassova N, Misra A, Padfield A, Parsons R, Pratt R, Robertson A, Walls S, Wong M, Roughley S. Hart T, et al. Among authors: lightowler s. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4241-4. doi: 10.1016/j.bmcl.2009.05.097. Epub 2009 May 29. Bioorg Med Chem Lett. 2009. PMID: 19515560
Measurement of anxiety in transgenic mice.
Weiss SM, Lightowler S, Stanhope KJ, Kennett GA, Dourish CT. Weiss SM, et al. Among authors: lightowler s. Rev Neurosci. 2000;11(1):59-74. doi: 10.1515/revneuro.2000.11.1.59. Rev Neurosci. 2000. PMID: 10716656 Review.
Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent.
Bromidge SM, Dabbs S, Davies DT, Davies S, Duckworth DM, Forbes IT, Gaster LM, Ham P, Jones GE, King FD, Mulholland KR, Saunders DV, Wyman PA, Blaney FE, Clarke SE, Blackburn TP, Holland V, Kennett GA, Lightowler S, Middlemiss DN, Trail B, Riley GJ, Wood MD. Bromidge SM, et al. Among authors: lightowler s. J Med Chem. 2000 Mar 23;43(6):1123-34. doi: 10.1021/jm990388c. J Med Chem. 2000. PMID: 10737744
1-[2-[(Heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orally active 5-HT2C receptor inverse agonists.
Bromidge SM, Davies S, Duckworth DM, Forbes IT, Jones GE, Jones J, King FD, Blackburn TP, Holland V, Kennett GA, Lightowler S, Middlemiss DN, Riley GJ, Trail B, Wood MD. Bromidge SM, et al. Among authors: lightowler s. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1867-70. doi: 10.1016/s0960-894x(00)00365-6. Bioorg Med Chem Lett. 2000. PMID: 10969987
1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents.
Bromidge SM, Dabbs S, Davies S, Duckworth DM, Forbes IT, Jones GE, Jones J, King FD, Saunders DV, Blackburn TP, Holland V, Kennett GA, Lightowler S, Middlemiss DN, Riley GJ, Trail B, Wood MD. Bromidge SM, et al. Among authors: lightowler s. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1863-6. doi: 10.1016/s0960-894x(00)00364-4. Bioorg Med Chem Lett. 2000. PMID: 10969986
31 results