Wang J - Search Results

1

Synthesis of H-bonding probes of alpha7 nAChR agonist selectivity.

Wang J, Papke RL, Horenstein NA. Wang J, et al. Bioorg Med Chem Lett. 2009 Jan 15;19(2):474-6. doi: 10.1016/j.bmcl.2008.11.044. Epub 2008 Nov 18. Bioorg Med Chem Lett. 2009. PMID: 19081250 Free PMC article.

2

Cysteine accessibility analysis of the human alpha7 nicotinic acetylcholine receptor ligand-binding domain identifies L119 as a gatekeeper.

Papke RL, Stokes C, Williams DK, Wang J, Horenstein NA. Papke RL, et al. Among authors: wang j. Neuropharmacology. 2011 Jan;60(1):159-71. doi: 10.1016/j.neuropharm.2010.07.014. Epub 2010 Jul 27. Neuropharmacology. 2011. PMID: 20650284 Free PMC article.

3

Tethered agonist analogs as site-specific probes for domains of the human α7 nicotinic acetylcholine receptor that differentially regulate activation and desensitization.

Wang J, Horenstein NA, Stokes C, Papke RL. Wang J, et al. Mol Pharmacol. 2010 Dec;78(6):1012-25. doi: 10.1124/mol.110.066662. Epub 2010 Sep 7. Mol Pharmacol. 2010. PMID: 20823218 Free PMC article.

4

Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations.

Williams DK, Wang J, Papke RL. Williams DK, et al. Among authors: wang j. Biochem Pharmacol. 2011 Oct 15;82(8):915-30. doi: 10.1016/j.bcp.2011.05.001. Epub 2011 May 14. Biochem Pharmacol. 2011. PMID: 21575610 Free PMC article. Review.

5

Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states.

Williams DK, Wang J, Papke RL. Williams DK, et al. Among authors: wang j. Mol Pharmacol. 2011 Dec;80(6):1013-32. doi: 10.1124/mol.111.074302. Epub 2011 Sep 1. Mol Pharmacol. 2011. PMID: 21885620 Free PMC article.

6

Potential state-selective hydrogen bond formation can modulate activation and desensitization of the α7 nicotinic acetylcholine receptor.

Wang J, Papke RL, Stokes C, Horenstein NA. Wang J, et al. J Biol Chem. 2012 Jun 22;287(26):21957-69. doi: 10.1074/jbc.M112.339796. Epub 2012 May 3. J Biol Chem. 2012. PMID: 22556416 Free PMC article.

7

Synthesis and activity of substituted heteroaromatics as positive allosteric modulators for α4β2α5 nicotinic acetylcholine receptors.

Jin Z, Khan P, Shin Y, Wang J, Lin L, Cameron MD, Lindstrom JM, Kenny PJ, Kamenecka TM. Jin Z, et al. Among authors: wang j. Bioorg Med Chem Lett. 2014 Jan 15;24(2):674-8. doi: 10.1016/j.bmcl.2013.11.049. Epub 2013 Nov 28. Bioorg Med Chem Lett. 2014. PMID: 24365158 Free PMC article.

8

An Accessory Agonist Binding Site Promotes Activation of α4β2* Nicotinic Acetylcholine Receptors.

Wang J, Kuryatov A, Sriram A, Jin Z, Kamenecka TM, Kenny PJ, Lindstrom J. Wang J, et al. J Biol Chem. 2015 May 29;290(22):13907-18. doi: 10.1074/jbc.M115.646786. Epub 2015 Apr 13. J Biol Chem. 2015. PMID: 25869137 Free PMC article.

9

Unorthodox Acetylcholine Binding Sites Formed by α5 and β3 Accessory Subunits in α4β2* Nicotinic Acetylcholine Receptors.

Jain A, Kuryatov A, Wang J, Kamenecka TM, Lindstrom J. Jain A, et al. Among authors: wang j. J Biol Chem. 2016 Nov 4;291(45):23452-23463. doi: 10.1074/jbc.M116.749150. Epub 2016 Sep 19. J Biol Chem. 2016. PMID: 27645992 Free PMC article.

10

A Novel α2/α4 Subtype-selective Positive Allosteric Modulator of Nicotinic Acetylcholine Receptors Acting from the C-tail of an α Subunit.

Wang J, Kuryatov A, Jin Z, Norleans J, Kamenecka TM, Kenny PJ, Lindstrom J. Wang J, et al. J Biol Chem. 2015 Nov 27;290(48):28834-46. doi: 10.1074/jbc.M115.676551. Epub 2015 Oct 2. J Biol Chem. 2015. PMID: 26432642 Free PMC article.

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