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Synthesis and evaluation of N-methyl and S-methyl 11C-labeled 6-methylthio-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridines as radioligands for imaging beta-amyloid plaques in Alzheimer's disease.
Cai L, Liow JS, Zoghbi SS, Cuevas J, Baetas C, Hong J, Shetty HU, Seneca NM, Brown AK, Gladding R, Temme SS, Herman MM, Innis RB, Pike VW. Cai L, et al. J Med Chem. 2008 Jan 10;51(1):148-58. doi: 10.1021/jm700970s. Epub 2007 Dec 14. J Med Chem. 2008. PMID: 18078311
The PET radioligand [11C]MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain.
Yasuno F, Brown AK, Zoghbi SS, Krushinski JH, Chernet E, Tauscher J, Schaus JM, Phebus LA, Chesterfield AK, Felder CC, Gladding RL, Hong J, Halldin C, Pike VW, Innis RB. Yasuno F, et al. Among authors: gladding rl. Neuropsychopharmacology. 2008 Jan;33(2):259-69. doi: 10.1038/sj.npp.1301402. Epub 2007 Mar 28. Neuropsychopharmacology. 2008. PMID: 17392732
39 results