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Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition.
Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, Spellman PT, Shokat KM, Wyrobek AJ, Bissell MJ, McCormick F, Kuo WL, Mills GB, Gray JW, Korn WM. Mirzoeva OK, et al. Among authors: gascard p. Cancer Res. 2009 Jan 15;69(2):565-72. doi: 10.1158/0008-5472.CAN-08-3389. Cancer Res. 2009. PMID: 19147570 Free PMC article.
Rare somatic cells from human breast tissue exhibit extensive lineage plasticity.
Roy S, Gascard P, Dumont N, Zhao J, Pan D, Petrie S, Margeta M, Tlsty TD. Roy S, et al. Among authors: gascard p. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4598-603. doi: 10.1073/pnas.1218682110. Epub 2013 Mar 4. Proc Natl Acad Sci U S A. 2013. PMID: 23487770 Free PMC article. Clinical Trial.
Stromal directives can control cancer.
Tlsty TD, Gascard P. Tlsty TD, et al. Among authors: gascard p. Science. 2019 Jul 12;365(6449):122-123. doi: 10.1126/science.aaw2368. Science. 2019. PMID: 31296756 Free PMC article. No abstract available.
Epigenetic and transcriptional determinants of the human breast.
Gascard P, Bilenky M, Sigaroudinia M, Zhao J, Li L, Carles A, Delaney A, Tam A, Kamoh B, Cho S, Griffith M, Chu A, Robertson G, Cheung D, Li I, Heravi-Moussavi A, Moksa M, Mingay M, Hussainkhel A, Davis B, Nagarajan RP, Hong C, Echipare L, O'Geen H, Hangauer MJ, Cheng JB, Neel D, Hu D, McManus MT, Moore R, Mungall A, Ma Y, Plettner P, Ziv E, Wang T, Farnham PJ, Jones SJ, Marra MA, Tlsty TD, Costello JF, Hirst M. Gascard P, et al. Nat Commun. 2015 Feb 18;6:6351. doi: 10.1038/ncomms7351. Nat Commun. 2015. PMID: 25690954 Free PMC article.
66 results