Orzáez M - Search Results

1

A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint.

Mondragón L, Galluzzi L, Mouhamad S, Orzáez M, Vicencio JM, Vitale I, Moure A, Messeguer A, Perez-Paya E, Kroemer G. Mondragón L, et al. Among authors: orzaez m. Apoptosis. 2009 Feb;14(2):182-90. doi: 10.1007/s10495-008-0310-x. Apoptosis. 2009. PMID: 19152031

2

Molecules that modulate Apaf-1 activity.

Pérez-Payá E, Orzáez M, Mondragón L, Wolan D, Wells JA, Messeguer A, Vicent MJ. Pérez-Payá E, et al. Among authors: orzaez m. Med Res Rev. 2011 Jul;31(4):649-75. doi: 10.1002/med.20198. Epub 2010 Jan 22. Med Res Rev. 2011. PMID: 20099266 Free article. Review.

3

Conjugation of a novel Apaf-1 inhibitor to peptide-based cell-membrane transporters: effective methods to improve inhibition of mitochondria-mediated apoptosis.

Orzáez M, Mondragón L, Marzo I, Sanclimens G, Messeguer A, Pérez-Payá E, Vicent MJ. Orzáez M, et al. Peptides. 2007 May;28(5):958-68. doi: 10.1016/j.peptides.2007.02.014. Epub 2007 Mar 3. Peptides. 2007. PMID: 17408805 Free article.

4

Apaf1 inhibition promotes cell recovery from apoptosis.

Gortat A, Sancho M, Mondragón L, Messeguer À, Pérez-Payá E, Orzáez M. Gortat A, et al. Among authors: orzaez m. Protein Cell. 2015 Nov;6(11):833-43. doi: 10.1007/s13238-015-0200-2. Epub 2015 Sep 11. Protein Cell. 2015. PMID: 26361785 Free PMC article.

5

Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis.

Malet G, Martín AG, Orzáez M, Vicent MJ, Masip I, Sanclimens G, Ferrer-Montiel A, Mingarro I, Messeguer A, Fearnhead HO, Pérez-Payá E. Malet G, et al. Among authors: orzaez m. Cell Death Differ. 2006 Sep;13(9):1523-32. doi: 10.1038/sj.cdd.4401828. Epub 2005 Dec 9. Cell Death Differ. 2006. PMID: 16341125

6

Modulation of cellular apoptosis with apoptotic protease-activating factor 1 (Apaf-1) inhibitors.

Mondragón L, Orzáez M, Sanclimens G, Moure A, Armiñán A, Sepúlveda P, Messeguer A, Vicent MJ, Pérez-Payá E. Mondragón L, et al. Among authors: orzaez m. J Med Chem. 2008 Feb 14;51(3):521-9. doi: 10.1021/jm701195j. Epub 2008 Jan 16. J Med Chem. 2008. PMID: 18197610

7

Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity.

Orzáez M, Sancho M, Marchán S, Mondragón L, Montava R, Valero JG, Landeta O, Basañez G, Carbajo RJ, Pineda-Lucena A, Bujons J, Moure A, Messeguer A, Lagunas C, Herrero C, Pérez-Payá E. Orzáez M, et al. PLoS One. 2014 Oct 20;9(10):e110979. doi: 10.1371/journal.pone.0110979. eCollection 2014. PLoS One. 2014. PMID: 25330150 Free PMC article.

8

Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain.

Orzáez M, Gortat A, Sancho M, Carbajo RJ, Pineda-Lucena A, Palacios-Rodríguez Y, Pérez-Payá E. Orzáez M, et al. Apoptosis. 2011 May;16(5):460-7. doi: 10.1007/s10495-011-0582-4. Apoptosis. 2011. PMID: 21340509 Free article.

9

Synthesis of enantiomerically pure perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives exhibiting potent activity as apoptosis inhibitors.

Moure A, Orzáez M, Sancho M, Messeguer A. Moure A, et al. Among authors: orzaez m. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7097-9. doi: 10.1016/j.bmcl.2012.09.078. Epub 2012 Sep 29. Bioorg Med Chem Lett. 2012. PMID: 23079529

10

BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components.

Andreu-Fernández V, Genovés A, Messeguer A, Orzáez M, Sancho M, Pérez-Payá E. Andreu-Fernández V, et al. Among authors: orzaez m. PLoS One. 2013;8(2):e56881. doi: 10.1371/journal.pone.0056881. Epub 2013 Feb 21. PLoS One. 2013. PMID: 23437261 Free PMC article.

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