Keller TH - Search Results

1

Discovery of a non-peptidic inhibitor of west nile virus NS3 protease by high-throughput docking.

Ekonomiuk D, Su XC, Ozawa K, Bodenreider C, Lim SP, Yin Z, Keller TH, Beer D, Patel V, Otting G, Caflisch A, Huang D. Ekonomiuk D, et al. Among authors: keller th. PLoS Negl Trop Dis. 2009;3(1):e356. doi: 10.1371/journal.pntd.0000356. Epub 2009 Jan 13. PLoS Negl Trop Dis. 2009. PMID: 19159012 Free PMC article.

2

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.

Erbel P, Schiering N, D'Arcy A, Renatus M, Kroemer M, Lim SP, Yin Z, Keller TH, Vasudevan SG, Hommel U. Erbel P, et al. Among authors: keller th. Nat Struct Mol Biol. 2006 Apr;13(4):372-3. doi: 10.1038/nsmb1073. Epub 2006 Mar 12. Nat Struct Mol Biol. 2006. PMID: 16532006

3

Peptide inhibitors of West Nile NS3 protease: SAR study of tetrapeptide aldehyde inhibitors.

Knox JE, Ma NL, Yin Z, Patel SJ, Wang WL, Chan WL, Ranga Rao KR, Wang G, Ngew X, Patel V, Beer D, Lim SP, Vasudevan SG, Keller TH. Knox JE, et al. Among authors: keller th. J Med Chem. 2006 Nov 2;49(22):6585-90. doi: 10.1021/jm0607606. J Med Chem. 2006. PMID: 17064076

4

NMR study of complexes between low molecular mass inhibitors and the West Nile virus NS2B-NS3 protease.

Su XC, Ozawa K, Yagi H, Lim SP, Wen D, Ekonomiuk D, Huang D, Keller TH, Sonntag S, Caflisch A, Vasudevan SG, Otting G. Su XC, et al. Among authors: keller th. FEBS J. 2009 Aug;276(15):4244-55. doi: 10.1111/j.1742-4658.2009.07132.x. Epub 2009 Jul 3. FEBS J. 2009. PMID: 19583774 Free article.

5

Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead.

Yin Z, Patel SJ, Wang WL, Wang G, Chan WL, Rao KR, Alam J, Jeyaraj DA, Ngew X, Patel V, Beer D, Lim SP, Vasudevan SG, Keller TH. Yin Z, et al. Among authors: keller th. Bioorg Med Chem Lett. 2006 Jan 1;16(1):36-9. doi: 10.1016/j.bmcl.2005.09.062. Epub 2005 Oct 21. Bioorg Med Chem Lett. 2006. PMID: 16246553

6

Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors.

Yin Z, Patel SJ, Wang WL, Chan WL, Ranga Rao KR, Wang G, Ngew X, Patel V, Beer D, Knox JE, Ma NL, Ehrhardt C, Lim SP, Vasudevan SG, Keller TH. Yin Z, et al. Among authors: keller th. Bioorg Med Chem Lett. 2006 Jan 1;16(1):40-3. doi: 10.1016/j.bmcl.2005.09.049. Epub 2005 Oct 21. Bioorg Med Chem Lett. 2006. PMID: 16246563

7

Yellow fever virus NS3 protease: peptide-inhibition studies.

Löhr K, Knox JE, Phong WY, Ma NL, Yin Z, Sampath A, Patel SJ, Wang WL, Chan WL, Rao KRR, Wang G, Vasudevan SG, Keller TH, Lim SP. Löhr K, et al. Among authors: keller th. J Gen Virol. 2007 Aug;88(Pt 8):2223-2227. doi: 10.1099/vir.0.82735-0. J Gen Virol. 2007. PMID: 17622626

8

A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease.

Bodenreider C, Beer D, Keller TH, Sonntag S, Wen D, Yap L, Yau YH, Shochat SG, Huang D, Zhou T, Caflisch A, Su XC, Ozawa K, Otting G, Vasudevan SG, Lescar J, Lim SP. Bodenreider C, et al. Among authors: keller th. Anal Biochem. 2009 Dec 15;395(2):195-204. doi: 10.1016/j.ab.2009.08.013. Epub 2009 Aug 13. Anal Biochem. 2009. PMID: 19682971

9

Finding new medicines for flaviviral targets.

Keller TH, Chen YL, Knox JE, Lim SP, Ma NL, Patel SJ, Sampath A, Wang QY, Yin Z, Vasudevan SG. Keller TH, et al. Novartis Found Symp. 2006;277:102-14; discussion 114-9, 251-3. Novartis Found Symp. 2006. PMID: 17319157 Review.

10

Small molecule inhibitors that selectively block dengue virus methyltransferase.

Lim SP, Sonntag LS, Noble C, Nilar SH, Ng RH, Zou G, Monaghan P, Chung KY, Dong H, Liu B, Bodenreider C, Lee G, Ding M, Chan WL, Wang G, Jian YL, Chao AT, Lescar J, Yin Z, Vedananda TR, Keller TH, Shi PY. Lim SP, et al. Among authors: keller th. J Biol Chem. 2011 Feb 25;286(8):6233-40. doi: 10.1074/jbc.M110.179184. Epub 2010 Dec 8. J Biol Chem. 2011. PMID: 21147775 Free PMC article.

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