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Page 1
Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations.
Butini S, Brindisi M, Cosconati S, Marinelli L, Borrelli G, Coccone SS, Ramunno A, Campiani G, Novellino E, Zanoli S, Samuele A, Giorgi G, Bergamini A, Di Mattia M, Lalli S, Galletti B, Gemma S, Maga G. Butini S, et al. Among authors: giorgi g. J Med Chem. 2009 Feb 26;52(4):1224-8. doi: 10.1021/jm801395v. J Med Chem. 2009. PMID: 19170521
Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.
Campiani G, Butini S, Gemma S, Nacci V, Fattorusso C, Catalanotti B, Giorgi G, Cagnotto A, Goegan M, Mennini T, Minetti P, Di Cesare MA, Mastroianni D, Scafetta N, Galletti B, Stasi MA, Castorina M, Pacifici L, Ghirardi O, Tinti O, Carminati P. Campiani G, et al. Among authors: giorgi g. J Med Chem. 2002 Jan 17;45(2):344-59. doi: 10.1021/jm010982y. J Med Chem. 2002. PMID: 11784139
Novel potent 5-HT(3) receptor ligands based on the pyrrolidone structure: synthesis, biological evaluation, and computational rationalization of the ligand-receptor interaction modalities.
Cappelli A, Anzini M, Vomero S, Mennuni L, Makovec F, Doucet E, Hamon M, Menziani MC, De Benedetti PG, Giorgi G, Ghelardini C, Collina S. Cappelli A, et al. Among authors: giorgi g. Bioorg Med Chem. 2002 Mar;10(3):779-801. doi: 10.1016/s0968-0896(01)00332-7. Bioorg Med Chem. 2002. PMID: 11814868
Design, synthesis, structural studies, biological evaluation, and computational simulations of novel potent AT(1) angiotensin II receptor antagonists based on the 4-phenylquinoline structure.
Cappelli A, Pericot Mohr Gl Gl, Gallelli A, Rizzo M, Anzini M, Vomero S, Mennuni L, Ferrari F, Makovec F, Menziani MC, De Benedetti PG, Giorgi G. Cappelli A, et al. Among authors: giorgi g. J Med Chem. 2004 May 6;47(10):2574-86. doi: 10.1021/jm031100t. J Med Chem. 2004. PMID: 15115399
Further studies on imidazo[4,5-b]pyridine AT1 angiotensin II receptor antagonists. Effects of the transformation of the 4-phenylquinoline backbone into 4-phenylisoquinolinone or 1-phenylindene scaffolds.
Cappelli A, Pericot Mohr Gl, Giuliani G, Galeazzi S, Anzini M, Mennuni L, Ferrari F, Makovec F, Kleinrath EM, Langer T, Valoti M, Giorgi G, Vomero S. Cappelli A, et al. Among authors: giorgi g. J Med Chem. 2006 Nov 2;49(22):6451-64. doi: 10.1021/jm0603163. J Med Chem. 2006. PMID: 17064065
Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.
Marinozzi M, Serpi M, Amori L, Gavilan Diaz M, Costantino G, Meyer U, Flor PJ, Gasparini F, Heckendorn R, Kuhn R, Giorgi G, Hermit MB, Thomsen C, Pellicciari R. Marinozzi M, et al. Among authors: giorgi g. Bioorg Med Chem. 2007 May 1;15(9):3161-70. doi: 10.1016/j.bmc.2007.02.040. Epub 2007 Feb 22. Bioorg Med Chem. 2007. PMID: 17350267
Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5.
Pellicciari R, Sato H, Gioiello A, Costantino G, Macchiarulo A, Sadeghpour BM, Giorgi G, Schoonjans K, Auwerx J. Pellicciari R, et al. Among authors: giorgi g. J Med Chem. 2007 Sep 6;50(18):4265-8. doi: 10.1021/jm070633p. Epub 2007 Aug 9. J Med Chem. 2007. PMID: 17685603
579 results