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Incubation of antigen-sensitized T lymphocytes activated with bryostatin 1 + ionomycin in IL-7 + IL-15 increases yield of cells capable of inducing regression of melanoma metastases compared to culture in IL-2.
Le HK, Graham L, Miller CH, Kmieciak M, Manjili MH, Bear HD. Le HK, et al. Among authors: bear hd. Cancer Immunol Immunother. 2009 Oct;58(10):1565-76. doi: 10.1007/s00262-009-0666-y. Epub 2009 Feb 6. Cancer Immunol Immunother. 2009. PMID: 19198835 Free PMC article.
Bryostatin 1 activates T cells that have antitumor activity.
Tuttle TM, Inge TH, Wirt CP, Frank JL, McCrady CM, Bear HD. Tuttle TM, et al. Among authors: bear hd. J Immunother (1991). 1992 Aug;12(2):75-81. doi: 10.1097/00002371-199208000-00001. J Immunother (1991). 1992. PMID: 1504056
176 results