Dowd CS - Search Results

1

Structure-activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles.

Kim P, Zhang L, Manjunatha UH, Singh R, Patel S, Jiricek J, Keller TH, Boshoff HI, Barry CE 3rd, Dowd CS. Kim P, et al. Among authors: dowd cs. J Med Chem. 2009 Mar 12;52(5):1317-28. doi: 10.1021/jm801246z. J Med Chem. 2009. PMID: 19209889 Free PMC article.

2

The role of MmpL8 in sulfatide biogenesis and virulence of Mycobacterium tuberculosis.

Domenech P, Reed MB, Dowd CS, Manca C, Kaplan G, Barry CE 3rd. Domenech P, et al. Among authors: dowd cs. J Biol Chem. 2004 May 14;279(20):21257-65. doi: 10.1074/jbc.M400324200. Epub 2004 Mar 4. J Biol Chem. 2004. PMID: 15001577 Free article.

3

Prospects for clinical introduction of nitroimidazole antibiotics for the treatment of tuberculosis.

Barry CE 3rd, Boshoff HI, Dowd CS. Barry CE 3rd, et al. Among authors: dowd cs. Curr Pharm Des. 2004;10(26):3239-62. doi: 10.2174/1381612043383214. Curr Pharm Des. 2004. PMID: 15544513 Review.

4

Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis.

Manjunatha UH, Boshoff H, Dowd CS, Zhang L, Albert TJ, Norton JE, Daniels L, Dick T, Pang SS, Barry CE 3rd. Manjunatha UH, et al. Among authors: dowd cs. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):431-6. doi: 10.1073/pnas.0508392103. Epub 2005 Dec 30. Proc Natl Acad Sci U S A. 2006. PMID: 16387854 Free PMC article.

5

Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli.

Kim P, Zhang YM, Shenoy G, Nguyen QA, Boshoff HI, Manjunatha UH, Goodwin MB, Lonsdale J, Price AC, Miller DJ, Duncan K, White SW, Rock CO, Barry CE 3rd, Dowd CS. Kim P, et al. Among authors: dowd cs. J Med Chem. 2006 Jan 12;49(1):159-71. doi: 10.1021/jm050825p. J Med Chem. 2006. PMID: 16392800 Free PMC article.

6

Novel route to 5-position vinyl derivatives of thiolactomycin: Olefination vs. deformylation.

Kim P, Barry CE, Dowd CS. Kim P, et al. Among authors: dowd cs. Tetrahedron Lett. 2006 May 15;47(20):3447-3451. doi: 10.1016/j.tetlet.2006.03.058. Tetrahedron Lett. 2006. PMID: 16699591 Free PMC article.

7

SYNTHESIS AND SPECTROSCOPIC DIFFERENTIATION OF 2- AND 4-ALKOXYTHIOTETRONIC ACIDS.

Shenoy G, Kim P, Goodwin M, Nguyen QA, Barry CE, Dowd CS. Shenoy G, et al. Among authors: dowd cs. Heterocycles. 2004 Mar 1;63(3):519-527. doi: 10.3987/com-03-9947. Heterocycles. 2004. PMID: 16733529 Free PMC article.

8

Mycobacterium leprae is naturally resistant to PA-824.

Manjunatha UH, Lahiri R, Randhawa B, Dowd CS, Krahenbuhl JL, Barry CE 3rd. Manjunatha UH, et al. Among authors: dowd cs. Antimicrob Agents Chemother. 2006 Oct;50(10):3350-4. doi: 10.1128/AAC.00488-06. Antimicrob Agents Chemother. 2006. PMID: 17005816 Free PMC article.

9

Quantification of small molecule organic acids from Mycobacterium tuberculosis culture supernatant using ion exclusion liquid chromatography/mass spectrometry.

Goodwin MB, Boshoff HI, Barry CE 3rd, Dowd CS. Goodwin MB, et al. Among authors: dowd cs. Rapid Commun Mass Spectrom. 2006;20(22):3345-50. doi: 10.1002/rcm.2745. Rapid Commun Mass Spectrom. 2006. PMID: 17044117

10

Chemical genetics: an evolving toolbox for target identification and lead optimization.

Boshoff HI, Dowd CS. Boshoff HI, et al. Among authors: dowd cs. Prog Drug Res. 2007;64:49, 51-77. doi: 10.1007/978-3-7643-7567-6_3. Prog Drug Res. 2007. PMID: 17195471 Review.

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